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Multicenter randomized controlled trial of inhaled nitric oxide for pediatric acute respiratory distress syndrome.
Bronicki, Ronald A; Fortenberry, James; Schreiber, Michael; Checchia, Paul A; Anas, Nick G.
Afiliação
  • Bronicki RA; Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX. Electronic address: rxbronic@texaschildrens.org.
  • Fortenberry J; Children's Healthcare Atlanta, Emory University School of Medicine, Atlanta, GA.
  • Schreiber M; Comer Children's Hospital, University of Chicago, Chicago, IL.
  • Checchia PA; Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
  • Anas NG; Children's Hospital of Orange County, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
J Pediatr ; 166(2): 365-9.e1, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25454942
OBJECTIVES: To test the hypothesis that inhaled nitric oxide (iNO) would lead to improved oxygenation and a decrease in duration of mechanical ventilation in pediatric patients with acute respiratory distress syndrome. STUDY DESIGN: A total of 55 children with acute respiratory distress syndrome were enrolled from 9 centers. Patients were randomized to iNO or placebo and remained on the study drug until death, they were free of ventilator support, or day 28 after the initiation of therapy. RESULTS: Mean baseline oxygenation indexes (OIs) were 22.0 ± 18.4 and 25.6 ± 14.9 (iNO and placebo groups, respectively, P = .27). There was a trend toward an improved OI in the iNO group compared with the placebo group at 4 hours that became significant at 12 hours. There was no difference in the OI between groups at 24 hours. Days alive and ventilator free at 28 days was greater in the iNO group, 14.2 ± 8.1 and 9.1 ± 9.5 days (iNO and placebo groups, respectively, P = .05). Although overall survival at 28 days failed to reach statistical significance, 92% (22 of 24) in the iNO group and 72% (21 of 29) in the placebo group (P = .07), the rate of extracorporeal membrane oxygenation-free survival was significantly greater in those randomized to iNO 92% (22 of 24) vs 52% (15 of 29) for those receiving placebo (P < .01). CONCLUSION: The use of iNO was associated with a significantly reduced duration of mechanical ventilation and significantly greater rate of extracorporeal membrane oxygenation-free survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Óxido Nítrico Tipo de estudo: Clinical_trials / Observational_studies Limite: Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Óxido Nítrico Tipo de estudo: Clinical_trials / Observational_studies Limite: Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos