Your browser doesn't support javascript.
loading
Androgen therapy reverses injuries caused by ethanol consumption in the prostate: testosterone as a possible target to ethanol-related disorders.
Mendes, Leonardo O; Scarano, Wellerson R; Rochel-Maia, Sabrina S; Fioruci-Fontaneli, Beatriz A; Chuffa, Luiz G A; Anselmo-Franci, Janete A; Martinez, Francisco E.
Afiliação
  • Mendes LO; Structural and Cell Biology Program, State University of Campinas - UNICAMP, Campinas, SP, Brazil.
  • Scarano WR; Department of Morphology, Institute of Biosciences, UNESP - Univ Estadual Paulista, Botucatu, SP, Brazil.
  • Rochel-Maia SS; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, São José do Rio Preto, SP, Brazil.
  • Fioruci-Fontaneli BA; Structural and Cell Biology Program, State University of Campinas - UNICAMP, Campinas, SP, Brazil.
  • Chuffa LG; Department of Anatomy, Institute of Biosciences, UNESP - Univ Estadual Paulista, Botucatu, SP, Brazil.
  • Anselmo-Franci JA; Department of Morphology, Stomatology and Physiology, USP - Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
  • Martinez FE; Department of Anatomy, Institute of Biosciences, UNESP - Univ Estadual Paulista, Botucatu, SP, Brazil. Electronic address: martinez@ibb.unesp.br.
Life Sci ; 120: 22-30, 2015 Jan 01.
Article em En | MEDLINE | ID: mdl-25447451
AIMS: Chronic ethanol consumption leads to reproductive damages, since it can act directly in the tissues or indirectly, causing a hormonal imbalance. Prostate is a hormone-dependent gland and, consequently, susceptible to ethanol. The potential of testosterone therapy in the ethanol-related disorders was investigated in the prostate microenvironment. MAIN METHODS: UChB rats aged 90 days were divided into 2 experimental groups (n=20): C: drinking water only and EtOH: drinking 10% (v/v) ethanol at >2 g/kg body weight/day+water. At 150 days old, 10 rats from each group received subcutaneous injections of testosterone cypionate (5 mg/kg body weight) diluted in corn oil every other day for 4 weeks, constituting T and EtOH+T, while the remaining animals received corn oil as vehicle. Animals were euthanized at 180 days old, by decapitation. Blood was collected to obtain hormone concentrations and ventral prostate was dissected and processed for light microscope and molecular analyses. KEY FINDINGS: Ventral prostate weight, plasma testosterone and DHT and intraprostatic testosterone concentrations were increased after testosterone treatment. Plasma estradiol level was reduced in the EtOH+T. Inflammatory foci, metaplasia and epithelial atrophy were constantly found in the prostate of EtOH and were not observed after hormonal therapy. No differences were found in the expression of AR, ERß and DACH-1. Additionally, testosterone treatment down-regulated ERα and increased the e-cadherin and α-actinin immunoreactivities. SIGNIFICANCE: Testosterone was able to reverse damages caused by ethanol consumption in the prostate microenvironment and becomes a possible target to be investigated to ethanol-related disorders.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Testosterona / Consumo de Bebidas Alcoólicas / Androgênios Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Testosterona / Consumo de Bebidas Alcoólicas / Androgênios Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda