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Increased VEGFR2 and MMP9 protein levels are associated with epithelial dysplasia grading.
de Carvalho Fraga, Carlos Alberto; Farias, Lucyana Conceição; de Oliveira, Marcos Vinícius Macedo; Domingos, Patrícia Luciana Batista; Pereira, Camila Santos; Silva, Thiago Fonseca; Roy, Ashbeel; Gomez, Ricardo Santiago; de Paula, Alfredo Maurício Batista; Guimarães, André Luiz Sena.
Afiliação
  • de Carvalho Fraga CA; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • Farias LC; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • de Oliveira MV; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • Domingos PL; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • Pereira CS; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • Silva TF; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • Roy A; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario N6A 5K8, Canada.
  • Gomez RS; Department of Clinical, Surgery and Oral Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • de Paula AM; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
  • Guimarães AL; Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil. Electronic address: andreluizguimaraes@gmail.com.
Pathol Res Pract ; 210(12): 959-64, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25441661
The present study aimed to compare levels of VEGFR2 and MMP-9 among control, epithelial dysplasia (ED) and oral squamous cell carcinoma (OSCC) groups. We analyzed 48 patients with oral leukoplakia (OL), 20 patients with OSCC and 21 patients without OL and OSCC. Immunohistochemistry of VEGFR2 and MMP9 were performed and compared among groups. Analysis of tissue immunolocalization of VEGFR2 and MMP-9 assumed non-parametrical distribution and comparison between groups was performed using the Mann-Whitney and Kruskal-Wallis statistical tests. VEGFR2 and MMP9 immunoexpression appeared to correlate with the degree of dysplasia and was observed to increase in lesions with more severe dysplasia as compared to those with lower degrees of dysplasia. Immunoreactivity of MMP-9 was lower in the OL samples compared to the OSCC samples (p = 0.004). We observed no difference in VEGFR2 protein levels between OL and OSCC samples. A positive correlation was found between VEGFR2 and MMP-9 in OL samples (r = +0.452, p = 0.001), however, no correlation was found in OSCC samples (r = -0.042, p = 0.861). In conclusion, the results of the current study suggest that expression of MMP9 and VEGFR2 is associated with ED grading and MMP9 levels are increased in OSCC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Metaloproteinase 9 da Matriz / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Leucoplasia / Mucosa Bucal Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Metaloproteinase 9 da Matriz / Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Leucoplasia / Mucosa Bucal Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pathol Res Pract Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha