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Synthesis of a microhydrogel composite from cellulose nanowhiskers and starch for drug delivery.
Mauricio, Marcos R; da Costa, Pablo G; Haraguchi, Shirani K; Guilherme, Marcos R; Muniz, Edvani C; Rubira, Adley F.
Afiliação
  • Mauricio MR; Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
  • da Costa PG; Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
  • Haraguchi SK; Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
  • Guilherme MR; Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
  • Muniz EC; Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.
  • Rubira AF; Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil. Electronic address: afrubira@uem.br.
Carbohydr Polym ; 115: 715-22, 2015 Jan 22.
Article em En | MEDLINE | ID: mdl-25439953
This work describes the preparation of a microhydrogel composite from cellulose nanowhiskers (CNW) and starch in an ultrasound assisted-emulsion. CNW, which showed rod-like morphology, was obtained by acid hydrolysis of cane-based cellulose. The introduction of vinyl bonds to both CNW and starch enabled us to create the microhydrogel composite in which CNW played a role as a covalent cross-linker. Furthermore, CNW may act as an emulsifying agent for emulsion, improving both sphericity and homogeneity of the microparticles. The drug release was regulated in response to changes in the CNW amounts. The modeling of the release kinetics indicated that the drug release is driven by an anomalous mechanism and that the addition of CNW to starch microparticles led to differences in that mechanism. The release rate became ca. 2.9 times slower when CNW is added. When combined with starch, CNW played a role as a retardant factor for drug release.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amido / Celulose / Sistemas de Liberação de Medicamentos / Hidrogéis / Nanoestruturas Tipo de estudo: Prognostic_studies Idioma: En Revista: Carbohydr Polym Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amido / Celulose / Sistemas de Liberação de Medicamentos / Hidrogéis / Nanoestruturas Tipo de estudo: Prognostic_studies Idioma: En Revista: Carbohydr Polym Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido