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Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio.
Ururahy, Marcela Abbott Galvão; de Souza, Karla Simone Costa; Oliveira, Yonara Monique da Costa; Loureiro, Melina Bezerra; da Silva, Heglayne Pereira Vital; Freire-Neto, Francisco Paulo; Bezerra, João Felipe; Luchessi, André Ducati; Doi, Sonia Quateli; Hirata, Rosario Dominguez Crespo; Almeida, Maria das Graças; Arrais, Ricardo Fernando; Hirata, Mario Hiroyuki; de Rezende, Adriana Augusto.
Afiliação
  • Ururahy MA; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • de Souza KS; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Oliveira YM; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Loureiro MB; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • da Silva HP; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Freire-Neto FP; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59072970, Brazil.
  • Bezerra JF; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Luchessi AD; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Doi SQ; Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.
  • Hirata RD; Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, 05508900, Brazil.
  • Almeida Md; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Arrais RF; Department of Pediatrics, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
  • Hirata MH; Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, 05508900, Brazil.
  • de Rezende AA; Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59012570, Brazil.
Diabetes Metab Res Rev ; 31(5): 500-6, 2015 Jul.
Article em En | MEDLINE | ID: mdl-25384728
BACKGROUND: Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been considered as key factors in type 1 diabetes mellitus (T1DM) and diabetic nephropathy, thus, our aim was to investigate the association of IL6-174G>C (rs1800795) and -634C>G (rs1800796) polymorphisms with T1DM susceptibility and diabetic nephropathy. METHODS: These polymorphisms were analyzed in 144 children and adolescents with T1DM and 173 normoglycemic control subjects. Glycemic control, laboratory parameters of kidney function and serum lipids were evaluated. By studying only T1DM patients, we evaluated the polymorphisms associated with relevant biochemical parameters in various genetic models. RESULTS: Type 1 diabetes mellitus patients showed poor glycemic control and albumin-to-creatinine ratio, total cholesterol and LDL-cholesterol levels increased when compared with normoglycemic subjects (p < 0.001, p = 0.004 and p < 0.001, respectively). IL6-174C allele was associated with an increased risk of developing T1DM (OR = 1.53, CI = 1.01-2.31, p = 0.044). In the T1DM group, IL6-174CC carriers showed higher concentrations of glycated hemoglobin (p = 0.029), albumin-to-creatinine ratio (p = 0.021), total cholesterol (p = 0.010), and LDL-cholesterol (p = 0.002), when compared with GG+GC carriers. No association was found for the IL6-634C>G polymorphism. CONCLUSIONS: These results suggest that IL6-174G>C may contribute to T1DM and increased albumin-to-creatinine ratio as well as to poor glycemic control and hyperlipidemia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Diabetes Mellitus Tipo 1 / Nefropatias Diabéticas / Albuminúria / Hiperlipidemias Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Diabetes Metab Res Rev Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-6 / Diabetes Mellitus Tipo 1 / Nefropatias Diabéticas / Albuminúria / Hiperlipidemias Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Diabetes Metab Res Rev Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido