Your browser doesn't support javascript.
loading
Host modulation by a parasite: how Leishmania infantum modifies the intestinal environment of Lutzomyia longipalpis to favor its development.
Santos, Vania Cristina; Vale, Vladimir Fazito; Silva, Sydnei Magno; Nascimento, Alexandre Alves Sousa; Saab, Natalia Alvim Araujo; Soares, Rodrigo Pedro Pinto; Michalick, Marilene Suzan Marques; Araujo, Ricardo Nascimento; Pereira, Marcos Horacio; Fujiwara, Ricardo Toshio; Gontijo, Nelder Figueiredo.
Afiliação
  • Santos VC; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Vale VF; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Silva SM; Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.
  • Nascimento AA; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Saab NA; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Soares RP; Laboratory of Medical Entomology, Centro de Pesquisas Rene Rachou (CPqRR), Belo Horizonte, Minas Gerais, Brazil.
  • Michalick MS; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Araujo RN; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; National Institute of Science and Technology-Molecular Entomology, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, Distrito Federal, Brazil.
  • Pereira MH; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; National Institute of Science and Technology-Molecular Entomology, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, Distrito Federal, Brazil.
  • Fujiwara RT; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Gontijo NF; Department of Parasitology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil; National Institute of Science and Technology-Molecular Entomology, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia, Distrito Federal, Brazil.
PLoS One ; 9(11): e111241, 2014.
Article em En | MEDLINE | ID: mdl-25365351
Some reports have described the interference of Leishmania on sand flies physiology, and such behavior most likely evolved to favor the development and transmission of the parasite. Most of these studies showed that Leishmania could modulate the level of proteases in the midgut after an infective blood meal, and decreased proteolytic activity is indeed beneficial for the development of promastigotes in the gut of sand flies. In the present study, we performed a detailed investigation of the intestinal pH in Lutzomyia longipalpis females naturally infected with Leishmania infantum and investigated the production of trypsin by these insects using different approaches. Our results allowed us to propose a mechanism by which these parasites interfere with the physiology of L. longipalpis to decrease the production of proteolytic enzymes. According to our hypothesis L. infantum promastigotes indirectly interfere with the production of trypsin by modulating the mechanism that controls the intestinal pH via the action of a yet non-identified substance released by promastigote forms inside the midgut. This substance is not an acid, whose action would be restrict on to release H+ to the medium, but is a substance that is able to interfere with midgut physiology through a mechanism involving pH control. According to our hypothesis, as the pH decreases, the proteolytic enzymes efficiency is also reduced, leading to a decline in the supply of amino acids to the enterocytes: this decline reduces the stimulus for protease production because it is regulated by the supply of amino acids, thus leading to a delay in digestion.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psychodidae / Interações Hospedeiro-Parasita / Intestinos / Leishmania Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psychodidae / Interações Hospedeiro-Parasita / Intestinos / Leishmania Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos