[Is rituximab effective for induction of remission in lupus nephritis?]. / ¿Es efectivo el rituximab para la inducción de remisión en nefritis lúpica?
Medwave
; 14(7): e6010, 2014 Aug 25.
Article
em Es
| MEDLINE
| ID: mdl-25334007
The combination of cyclophosphamide and steroids constitutes the standard treatment in lupus nephritis requiring immunosuppressive therapy. However, it is associated with important adverse effects, so there is interest in alternative immunosuppressors such as rituximab. Searching in Epistemonikos database, which is maintained by screening 19 databases, we identified 5 systematic reviews including 24 studies. We combined the evidence using summary of findings tables following the GRADE approach and concluded there is uncertainty about the effects of rituximab in lupus nephritis because the certainty of the evidence is very low, probably leads to important adverse effects, and has high cost. Rituximab should not be used outside the context of a clinical trial, or only in cases where other treatments have failed and there are no resource constraints.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nefrite Lúpica
/
Anticorpos Monoclonais Murinos
/
Fatores Imunológicos
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
Es
Revista:
Medwave
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
Chile