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Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis.
Cavalcante, José Roosevelt; Sampaio, João Paulo Aguiar; Maia Filho, João Tarcísio Alves; Vieira, Renato Braga; Eleutério, José; Lima, Roberto César Pereira; Ribeiro, Ronaldo Albuquerque; Almeida, Paulo Roberto Carvalho.
Afiliação
  • Cavalcante JR; School Maternity, Federal University of Ceara, Fortaleza, CE, Brazil.
  • Sampaio JP; Department of Pathology and Forensic Medicine, UFC, Fortaleza, CE, Brazil.
  • Maia Filho JT; Faculty of Medicine, UFC, Fortaleza, CE, Brazil.
  • Vieira RB; Faculty of Medicine, UFC, Fortaleza, CE, Brazil.
  • Eleutério J; Department of Maternal and Child Health, UFC, Fortaleza, CE, Brazil.
  • Lima RC; Department of Physiology and Pharmacology, UFC, Fortaleza, CE, Brazil.
  • Ribeiro RA; Department of Physiology and Pharmacology, UFC, Fortaleza, CE, Brazil.
  • Almeida PR; Department of Pathology and Forensic Medicine, UFC, Fortaleza, CE, Brazil.
Acta Cir Bras ; 29(10): 667-74, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25317999
PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Caderinas / Cervicite Uterina / Neoplasias do Colo do Útero / Lesões Intraepiteliais Escamosas Cervicais Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Caderinas / Cervicite Uterina / Neoplasias do Colo do Útero / Lesões Intraepiteliais Escamosas Cervicais Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Middle aged Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil