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Interaction between µ-opioid and 5-HT1A receptors in the regulation of panic-related defensive responses in the rat dorsal periaqueductal grey.
Rangel, Marcel P; Zangrossi, Hélio; Roncon, Camila M; Graeff, Frederico G; Audi, Elisabeth A.
Afiliação
  • Rangel MP; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Brazil.
  • Zangrossi H; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil NAP-NuPNE - Neurobiology of Emotion Research Centre, University of São Paulo, Ribeirão Preto, Brazil.
  • Roncon CM; Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.
  • Graeff FG; INeC - Institute of Behavioral Neuroscience, Ribeirão Preto, Brazil NAP-NuPNE - Neurobiology of Emotion Research Centre, University of São Paulo, Ribeirão Preto, Brazil.
  • Audi EA; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Brazil INeC - Institute of Behavioral Neuroscience, Ribeirão Preto, Brazil elisabethaudi8@gmail.com.
J Psychopharmacol ; 28(12): 1155-60, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25315826
A wealth of evidence indicates that the activation of 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal grey matter (dPAG) inhibits escape, a panic-related defensive behaviour. Results that were previously obtained with the elevated T-maze test of anxiety/panic suggest that 5-HT1A and µ-opioid receptors in this midbrain area work together to regulate this response. To investigate the generality of this finding, we assessed whether the same cooperative mechanism is engaged when escape is evoked by a different aversive stimulus electrical stimulation of the dPAG. Administration of the µ-receptor blocker CTOP into the dPAG did not change the escape threshold, but microinjection of the µ-receptor agonist DAMGO (0.3 and 0.5 nmol) or the 5-HT1A receptor agonist 8-OHDPAT (1.6 nmol) increased this index, indicating a panicolytic-like effect. Pretreatment with CTOP antagonised the anti-escape effect of 8-OHDPAT. Additionally, combined administration of subeffective doses of DAMGO and 8-OHDPAT increased the escape threshold, indicating drug synergism. Therefore, regardless of the aversive nature of the stimulus, µ-opioid and 5-HT1A receptors cooperatively act to regulate escape behaviour. A better comprehension of this mechanism might allow for new therapeutic strategies for panic disorder.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pânico / Substância Cinzenta Periaquedutal / Receptores Opioides mu / Receptor 5-HT1A de Serotonina / Reação de Fuga Limite: Animals Idioma: En Revista: J Psychopharmacol Assunto da revista: PSICOFARMACOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pânico / Substância Cinzenta Periaquedutal / Receptores Opioides mu / Receptor 5-HT1A de Serotonina / Reação de Fuga Limite: Animals Idioma: En Revista: J Psychopharmacol Assunto da revista: PSICOFARMACOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos