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Potential drug interactions prevalence in intensive care units. / Prevalência de potenciais interações medicamentosas droga-droga em unidades de terapia intensiva.
Hammes, Jean André; Pfuetzenreiter, Felipe; Silveira, Fabrízio da; Koenig, Alvaro; Westphal, Glauco Adrieno.
Afiliação
  • Hammes JA; Universidade da Região de Joinville, Joinville, SC, Brasil.
  • Pfuetzenreiter F; Universidade da Região de Joinville, Joinville, SC, Brasil.
  • Silveira Fd; Universidade da Região de Joinville, Joinville, SC, Brasil.
  • Koenig A; Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brasil.
  • Westphal GA; Departamento de Medicina, Universidade da Região de Joinville, Joinville, SC, Brasil.
Rev Bras Ter Intensiva ; 20(4): 349-54, 2008 Dec.
Article em En, Pt | MEDLINE | ID: mdl-25307239
OBJECTIVES: Drug interactions occur when effects and/or toxicity of a drug are affected by presence of another drug. They are usually unpredictable and undesirable. A study was conducted to verify the prevalence and clinical value of potential drug interactions in intensive care units METHODS: All patients, of three intensive care units were included in a cross-sectional study, over a period of two months. Patients with less than a 2 days length of stay were excluded. Data were collected from twenty-four hour prescriptions and all possible paired combinations drug-drug were recorded. Prevalence and clinical value (significance) were checked at the end of follow-up. RESULTS: One hundred and forty patients were analyzed, 67.1% presented with some significant potential drug interactions and of the 1069 prescriptions, 39.2% disclosed the same potential. Of 188 different potential drug interactions, 29 were considered highly significant. Univariate analysis showed that in the group with significant potential drug interactions a higher number of different drugs, drugs/day had been used, there were more prescribing physicians and extended stay in intensive care units. Adjusted to the multivariate logistic regression model, only the number of drugs/day correlated with increased risk of significant potential drug interaction (p = 0.0011) and, furthermore that use of more than 6 drugs/day increased relative risk by 9.8 times. CONCLUSIONS: Critically ill patients are submitted to high risk of potential drug interactions and the number of drugs/day has a high positive predictive value for these interactions. Therefore, it is imperative that critical care physicians be constantly alert to recognize this problem and provide appropriate mechanisms for management, thereby reducing adverse outcomes.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En / Pt Revista: Rev Bras Ter Intensiva Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En / Pt Revista: Rev Bras Ter Intensiva Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil