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[Lack of protection against gentamicin ototoxicity by auditory conditioning with noise]. / Falta de proteção contra a ototoxicidade da gentamicina pelo condicionamentoauditivo com ruído.
Strose, Alex; Hyppolito, Miguel Ângelo; Colombari, Gleice Cristina; Rossato, Maria; Oliveira, Jose Antônio Aparecido de.
Afiliação
  • Strose A; Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: alexstrose@yahoo.com.br.
  • Hyppolito MÂ; Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Colombari GC; Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Rossato M; Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
  • Oliveira JA; Department of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Braz J Otorhinolaryngol ; 80(5): 390-6, 2014.
Article em Pt | MEDLINE | ID: mdl-25303813
INTRODUCTION: Auditory conditioning consists of the pre-exposure to low levels of a potential harmful agent to protect against a subsequent harmful exposure. OBJECTIVE: To confirm if conditioning with an agent different from that used to cause the trauma can also be effective. METHODS: This was an experimental study with 17 guinea pigs, divided into three groups: an ototoxic control group (Cont) that received intramuscular administration of gentamicin 160 mg/kg/day for ten consecutive days, but no sound exposure; a sound control group (Sound) that was exposed to 85 dB broadband noise centered at 4 kHz, 30 min each day for ten consecutive days, but received no ototoxic medications; and an experimental group (Expt) that received sound exposure identical to the Sound group and after each noise presentation, received gentamicin similarly to Cont group. The animals were evaluated by distortion product otoacoustic emissions (DPOAEs), brainstem auditory evoked potentials (BAEPs), and scanning electron microscopy. RESULTS: The animals that were conditioned with noise did not show any protective effect compared with the ones that received only the ototoxic gentamicin administration. This lack of protection was observed functionally and morphologically. CONCLUSION: Conditioning with 85 dB broadband noises, 30 min a day for ten consecutive days does not protect against an ototoxic gentamicin administration of 160 mg/kg/day for ten consecutive days in the guinea pig.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Acústica / Gentamicinas / Cóclea / Perda Auditiva Provocada por Ruído Limite: Animals Idioma: Pt Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estimulação Acústica / Gentamicinas / Cóclea / Perda Auditiva Provocada por Ruído Limite: Animals Idioma: Pt Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil