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Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression.
Dean, Olivia M; Turner, Alyna; Malhi, Gin S; Ng, Chee; Cotton, Sue M; Dodd, Seetal; Sarris, Jerome; Samuni, Yuval; Tanious, Michelle; Dowling, Nathan; Waterdrinker, Astrid; Smith, Deidre; Berk, Michael.
Afiliação
  • Dean OM; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
  • Turner A; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
  • Malhi GS; Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Ng C; Department of Psychiatry University of Melbourne, Melbourne, Australia.
  • Cotton SM; Orygen Youth Health Research Centre, Melbourne, Australia.
  • Dodd S; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
  • Sarris J; University of Melbourne, Melbourne, Australia.
  • Samuni Y; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
  • Tanious M; Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia.
  • Dowling N; Department of Psychiatry University of Melbourne, Melbourne, Australia.
  • Waterdrinker A; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
  • Smith D; Department of Psychiatry University of Melbourne, Melbourne, Australia.
  • Berk M; IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
Braz J Psychiatry ; 37(1): 3-12, 2015.
Article em En | MEDLINE | ID: mdl-25295681
OBJECTIVE: Bipolar disorder places a significant burden on individuals, caregivers and family, and the broader community. Current treatments are believed to be more effective against manic symptoms, leaving a shortfall in recovery during the depressive phase of the illness. The current study draws on recent evidence suggesting that, in addition to increased oxidative load, alterations in mitochondrial function occur in bipolar disorder. METHODS: This 16-week study aims to explore the potential benefits of N-acetylcysteine (NAC) alone or in combination (CT) with selected nutraceuticals believed to enhance mitochondrial function. The study includes adults diagnosed with bipolar disorder currently experiencing an episode of depression. Participants are asked to take NAC, CT, or placebo in addition to any usual treatments. A post-discontinuation visit is conducted 4 weeks following the treatment phase. RESULTS: The primary outcome of the study will be mean change on the Montgomery-Asberg Depression Rating Scale. Secondary outcomes include functioning, substance use, mania ratings, and quality of life. Blood samples will be collected at baseline and week 16 to explore biochemical alterations following treatment. CONCLUSION: This study may provide a novel adjunctive treatment for bipolar depression. Analysis of biological samples may assist in understanding the therapeutic benefits and the underlying etiology of bipolar depression. TRIAL REGISTRATION: Australian and New Zealand Clinical Trial Registry ACTRN12612000830897.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Transtorno Bipolar / Sequestradores de Radicais Livres / Suplementos Nutricionais / Doenças Mitocondriais / Transtorno Depressivo Tipo de estudo: Clinical_trials Aspecto: Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Transtorno Bipolar / Sequestradores de Radicais Livres / Suplementos Nutricionais / Doenças Mitocondriais / Transtorno Depressivo Tipo de estudo: Clinical_trials Aspecto: Patient_preference Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz J Psychiatry Assunto da revista: PSIQUIATRIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália País de publicação: Brasil