Your browser doesn't support javascript.
loading
Biocompatibility of new calcium aluminate cement: tissue reaction and expression of inflammatory mediators and cytokines.
Garcia, Lucas da Fonseca Roberti; Huck, Claudia; Menezes de Oliveira, Letícia; de Souza, Pedro Paulo Chaves; de Souza Costa, Carlos Alberto.
Afiliação
  • Garcia Lda F; Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
  • Huck C; Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
  • Menezes de Oliveira L; Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
  • de Souza PP; Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista, Araraquara, São Paulo, Brazil.
  • de Souza Costa CA; Department of Physiology and Pathology, Araraquara School of Dentistry, Univ Estadual Paulista, Araraquara, São Paulo, Brazil. Electronic address: casouzac@foar.unesp.br.
J Endod ; 40(12): 2024-9, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25266467
INTRODUCTION: The aim of this study was to evaluate the biocompatibility of a new calcium aluminate cement (EndoBinder) in subcutaneous tissue of rats in comparison with mineral trioxide aggregate and calcium hydroxide hard-setting cement. METHODS: Polyethylene tubes (1.5 × 10 mm) containing the dental cements were implanted into dorsal subcutaneous tissue of 30 rats. After experimental periods of 7, 30, and 90 days, biopsies were performed for tissue response analysis under optical light microscope. The mRNA extraction was performed for molecular evaluation of the inflammatory process in the peri-implant tissue, which was submitted to quantitative real-time polymerase chain reaction analysis for inflammatory mediators and cytokines TNF-α, Ptges2, Il-1ß, Il-4, and Il-10. RESULTS: On the basis of the score used to grade the tissue reaction (0-3), EndoBinder (0) presented no inflammatory reaction after the 90-day period, a similar result to mineral trioxide aggregate and calcium hydroxide. The thickness of inflammatory capsules (µm) also presented significant decrease during the course of periods (P < .05). As regards expression of inflammatory mediators, Ptges2 and Il-10 were detected only at 7 and 30 days, with no statistically significant difference among the experimental groups (P > .05). CONCLUSIONS: EndoBinder induced limited inflammatory reaction. It was considered biocompatible when tested in subcutaneous tissue of rats.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Materiais Biocompatíveis / Citocinas / Compostos de Cálcio / Compostos de Alumínio / Mediadores da Inflamação / Tela Subcutânea Limite: Animals Idioma: En Revista: J Endod Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Restauradores do Canal Radicular / Materiais Biocompatíveis / Citocinas / Compostos de Cálcio / Compostos de Alumínio / Mediadores da Inflamação / Tela Subcutânea Limite: Animals Idioma: En Revista: J Endod Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos