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Human papillomavirus among women with atypical squamous cells of undetermined significance in southern Brazil.
Paesi, Suelen; Correa, Leonardo; Tregnago, Márcia Caldart; Mandelli, Jovana; Roesch-Ely, Mariana.
Afiliação
  • Paesi S; Molecular Diagnostics Laboratory, Biotechnology Institute, Universidade de Caxias do Sul, Caxias do Sul, Brazil. Electronic address: sopaesi@ucs.br.
  • Correa L; Molecular Diagnostics Laboratory, Biotechnology Institute, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
  • Tregnago MC; Center of Medical Pathology of Caxias do Sul, Caxias do Sul, Brazil.
  • Mandelli J; Molecular Diagnostics Laboratory, Biotechnology Institute, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
  • Roesch-Ely M; Laboratory of Genomics, Proteomics and DNA Repair, Biotechnology Institute, Universidade de Caxias do Sul, Caxias do Sul, Brazil.
Int J Gynaecol Obstet ; 128(1): 23-6, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25257569
OBJECTIVE: To determine the prevalence of atypical squamous cells of undetermined significance (ASCUS) and human papillomavirus (HPV) genotypes in a population in southern Brazil. METHODS: In a retrospective cross-sectional study, the prevalence of ASCUS was determined among women aged 20-60 years who were referred to a private medical center in Caxias do Sul by a gynecologist for assessment of a cervical condition between January 1, 2010, and September 30, 2011. Histologic and cytologic samples were tested for HPV, and polymerase chain reaction (PCR) was used to genotype any HPV DNA identified. RESULTS: Among the 250 included women, 25 (10.0%) had ASCUS. HPV DNA was found in 15 (60.0%) women with ASCUS and 115 (51.1%) of the 225 without ASCUS. Viral typing showed that 7 (46.7%) HPV-positive women with ASCUS had multiple infections with up to five different genotypes. Both low- and high-risk HPV genotypes were found in ASCUS samples; the most prevalent genotypes were HPV6/HPV11 (affecting 10 [66.7%] women), HPV51 (6 [40.0%]), and HPV16 (6 [40.0%]). CONCLUSION: ASCUS is not an indication of HPV infection. HPV screening and genotyping would benefit women with ASCUS, because treatment can be planned according to risk of carcinogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Infecções por Papillomavirus / Células Escamosas Atípicas do Colo do Útero / Lesões Intraepiteliais Escamosas Cervicais Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Gynaecol Obstet Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Infecções por Papillomavirus / Células Escamosas Atípicas do Colo do Útero / Lesões Intraepiteliais Escamosas Cervicais Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Int J Gynaecol Obstet Ano de publicação: 2015 Tipo de documento: Article País de publicação: Estados Unidos