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Clinical utility of prostate-specific antigen mass ratio for prediction of prostate cancer detection on a repeated prostate biopsy.
Lee, Won Ki; Lee, Sangchul; Hong, Sung Kyu; Lee, Sang Eun; Choi, Won Suk; Byun, Seok-Soo.
Afiliação
  • Lee WK; Department of Urology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
  • Lee S; Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Hong SK; Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Lee SE; Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Choi WS; Department of Urology, Choi Won Suk Urology Clinic, Yongin, Korea.
  • Byun SS; Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
Int Braz J Urol ; 40(4): 484-92, 2014.
Article em En | MEDLINE | ID: mdl-25251953
PURPOSE: To assess the clinical utility of the prostate-specific antigen mass ratio (PSA- MR), a newly developed PSA derivative, simply defined as the (i) PSA density (PSA-D) multiplied by the plasma volume or (ii) total PSA amount in circulation per prostate volume, for predicting prostate cancer (PCa) among men undergoing repeated prostate biopsy (PBx). MATERIALS AND METHODS: Patients (n = 286), who underwent a repeated PBx, were analyzed. The various parameters associated with PCa detection were noted in each patient. PSA-MR was also calculated. RESULTS: PCa was detected in 63 (22.0%) of 286 patients. PSA-MR was the independent predictor in the univariate- and multivariate logistic regression analyses (OR = 3.448, p = 0.001 and OR = 13.430, p = 0.033, respectively). A nomogram that incorporated PSA-MR was considered a useful tool (predictive accuracy: 79.2%, 95% CI: 0.726-0.858, p < 0.001). Furthermore, a nomogram that incorporated PSA-MR would have avoided 59.6% of unnecessary repeated PBx. The predictive accuracy of PSA-MR was also superior to that of PSA or PSA-D (p = 0.013 and 0.009, respectively). CONCLUSIONS: PSA-MR was an independent predictor, and its consideration would have avoided 59.6% of unnecessary repeated PBx for PCa detection. PSA-MR was also superior than PSA or PSA-D. Our results support the use of PSA-MR to facilitate counseling with patients after a negative initial PBx, and use of PSA-MR might reduce further unnecessary biopsies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Neoplasias da Próstata / Antígeno Prostático Específico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male / Middle aged Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Neoplasias da Próstata / Antígeno Prostático Específico Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Male / Middle aged Idioma: En Revista: Int Braz J Urol Assunto da revista: UROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil