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Ghrelin, leptin and adiponectin levels in Gaucher disease type I patients on enzyme replacement therapy.
Doneda, Divair; Lopes, André L; Teixeira, Bruno C; Mittelstadt, Suzana D; Moulin, Cileide C; Schwartz, Ida V D.
Afiliação
  • Doneda D; LTD Laboratory, Nutrition Program, Medical School, Universidade Federal do Rio Grande do Sul, Brazil.
  • Lopes AL; School of Physical Education, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Physical Education Program, University Center UNIVATES, Lageado, RS, Brazil.
  • Teixeira BC; School of Physical Education, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Mittelstadt SD; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Moulin CC; Centre for Studies in Food and Nutrition (CESAN), HCPA/UFRGS, Brazil; Department of Internal Medicine, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Schwartz IV; Post-Graduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, Brazil; Laboratory B.R.A.I.N, HCPA/UFRGS, Brazil; Genetics Department, Universidade Federal do Rio Grande do Sul, Brazil. Electronic address: idadschwartz@gmail.com.
Clin Nutr ; 34(4): 727-31, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25239509
BACKGROUND: Gaucher disease type I (GD type I) is characterized by clinical heterogeneity and is associated with metabolic abnormalities such as increased basal metabolic rate. OBJECTIVE: To evaluate ghrelin, leptin and adiponectin levels in patients with GD type I on enzyme replacement therapy (ERT). SUBJECTS AND METHODS: A cross-sectional study of patients with GD type I (n = 15), matched for sex, age and BMI with healthy controls. The levels of glucose, insulin, ghrelin, leptin and adiponectin were assessed in both groups. Insulin resistance was defined by the index HOMA-IR. RESULTS: Eight patients had adequate weight, seven were overweight (4 preobese, 3 obese class I). Eight patients presented metabolic syndrome, five of whom with insulin resistance. The median levels of ghrelin, leptin and adiponectin of the patients did not differ from those of the controls. Ghrelin and adiponectin levels were correlated with each other; inversely correlated with BMI, waist circumference and triglyceride levels; and directly correlated with HDL-cholesterol. Leptin levels were inversely correlated with LDL-cholesterol and directly correlated with BMI, waist circumference, enzyme dosage, triglycerides, insulin, and HOMA-IR. CONCLUSIONS: Metabolic syndrome and overweight appear to be common in patients with GD type I on ERT. As leptin was strongly associated with insulin and HOMA index, it could become a biomarker to assess early evidence of insulin resistance in patients with GD. Further studies are needed to investigate the associations found.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leptina / Adiponectina / Grelina / Terapia de Reposição de Enzimas / Doença de Gaucher Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Nutr Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leptina / Adiponectina / Grelina / Terapia de Reposição de Enzimas / Doença de Gaucher Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Nutr Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido