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Vitamin E concentrations in adults with HIV/AIDS on highly active antiretroviral therapy.
Itinoseki Kaio, Daniella J Itinoseki; Rondó, Patricia Helen C; Luzia, Liania Alves; Souza, José Maria P; Firmino, Aline Vale; Santos, Sigrid Sousa.
Afiliação
  • Itinoseki Kaio DJ; Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. daniellinhait@yahoo.com.br.
  • Rondó PH; Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. phcrondo@usp.br.
  • Luzia LA; Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. lianialuzia@usp.br.
  • Souza JM; Department of Epidemiology, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. jmpsouza@usp.br.
  • Firmino AV; Department of Nutrition, Public Health School, University of São Paulo, Av. Dr. Arnaldo, 715, CEP-01246-904 São Paulo, Brazil. alinefir@gmail.com.
  • Santos SS; Department of Medicine, Center for Biological and Health Sciences, Federal University of São Carlos, Rodovia Washington Luís, km 235, CEP-13565-905 São Carlos, Brazil. sigridsantos@uol.com.br.
Nutrients ; 6(9): 3641-52, 2014 Sep 15.
Article em En | MEDLINE | ID: mdl-25225815
HIV/AIDS patients are probably more predisposed to vitamin E deficiency, considering that they are more exposed to oxidative stress. Additionally, there are an extensive number of drugs in the highly active antiretroviral therapy (HAART) regimens that may interfere with vitamin E concentrations. The objective of this study was to compare serum concentrations of alpha-tocopherol in 182 HIV/AIDS patients receiving different HAART regimens. The patients were divided into three groups according to regimen: nucleoside analog reverse-transcriptase inhibitors (NRTIs) + non-nucleoside analog reverse-transcriptase inhibitors (NNRTIs); NRTIs + protease inhibitors + ritonavir; NRTIs + other classes. Alpha-tocopherol was assessed by high-performance liquid chromatography. Multiple linear regression analysis was used to evaluate the effects of HAART regimen, time of use, and compliance with the regimen on alpha-tocopherol concentrations. Alpha-tocopherol concentrations were on average 4.12 µmol/L lower for the NRTIs + other classes regimen when compared to the NRTIs + NNRTIs regimen (p = 0.037). A positive association (p < 0.001) was observed between alpha-tocopherol and cholesterol concentrations, a finding due, in part, to the relationship between liposoluble vitamins and lipid profile. This study demonstrated differences in alpha-tocopherol concentrations between patients using different HAART regimens, especially regimens involving the use of new drugs. Long-term prospective cohort studies are needed to monitor vitamin E status in HIV/AIDS patients since the beginning of treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina E / Infecções por HIV / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade / Alfa-Tocoferol Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deficiência de Vitamina E / Infecções por HIV / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade / Alfa-Tocoferol Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça