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First baseline of circulating genotypic lineages of Mycobacterium tuberculosis in patients from the brazilian borders with Argentina and Paraguay.
Machado, Luzia Neri C; Marcondes, Nadir R; Leite, Clarice Q Fijimura; Santos, Adolfo C Barreto; Pavan, Fernando Rogério; Baldin, Vanessa Pietrowski; Castilho, Aline Lemes; Siqueira, Vera Lúcia D; Baeza, Lilian Cristiane; Berghs, Henri; Cardoso, Rosilene Fressatti.
Afiliação
  • Machado LN; Postgraduate Program in Biosciences and Physiopatology, State University of Maringá, Maringá, Paraná, Brazil.
  • Marcondes NR; Center of Medical and Pharmaceutical Sciences, State University of Western Paraná, Cascavel, Paraná, Brazil.
  • Leite CQ; School of Pharmaceutical Sciences, Department of Biological Sciences, Paulista State University, Araraquara, São Paulo, Brazil.
  • Santos AC; School of Pharmaceutical Sciences, Department of Biological Sciences, Paulista State University, Araraquara, São Paulo, Brazil.
  • Pavan FR; School of Pharmaceutical Sciences, Department of Biological Sciences, Paulista State University, Araraquara, São Paulo, Brazil.
  • Baldin VP; Postgraduate Program in Biosciences and Physiopatology, State University of Maringá, Maringá, Paraná, Brazil.
  • Castilho AL; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
  • Siqueira VL; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
  • Baeza LC; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
  • Berghs H; Fairport Ltda, São Paulo, Brazil.
  • Cardoso RF; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.
PLoS One ; 9(9): e107106, 2014.
Article em En | MEDLINE | ID: mdl-25202909
BACKGROUND: At the triple border Brazil/Paraguay/Argentina there is easy mobility from one city to another for economic and tourism activities. This constant and fast population mobility is mainly to visit Iguazu Falls, in the Iguazu River, on the border of the Brazilian state of Paraná and the Argentina. As the incidence of tuberculosis is high in this setting, our study aimed to establish a first baseline of circulating genotypic lineages of Mycobacterium tuberculosis. METHODOLOGY/PRINCIPAL FINDINGS: This study included 120 patients from 10 cities in southwestern Paraná, Brazil with pulmonary symptoms, from July 2009 to July 2011. Information about sex, age, clinical features and address was collected by reviewing the national tuberculosis notification database. Of these, 96 (80%) isolates were identified as M. tuberculosis and 22 (22.9%) were drug resistant (20, 20.8% INH mono-resistant and 2, 2.1% multidrug-resistant). All isolates were subjected to genotyping by Spoligotyping and MIRU-VNTR typing. The distribution of the isolates analyzed by spoligotyping revealed 30 distinct patterns. The four mainly detected clades were Latin American and Mediterranean (LAM), ill-defined T, Haarlem (H) and S. The MIRU-VNTR showed 85 distinct patterns. Spoligotyping combined to MIRU-VNTR allowed 90 distinct patterns. CONCLUSIONS/SIGNIFICANCE: Our study demonstrated that there is significant molecular diversity in circulating M. tuberculosis, with predominance of the LAM and T clades in cities of southwestern Paraná, Brazil, bordering Argentina and Paraguay.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Argentina / Brasil / Paraguay Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Argentina / Brasil / Paraguay Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos