[Genetic polymorphism of isoniazid acetylation in Chilean patients with tuberculosis]. / Polimorfismo genético de acetilación de isoniazida en pacientes tuberculosos Chilenos.
Rev Med Chil
; 117(12): 1339-43, 1989 Dec.
Article
em Es
| MEDLINE
| ID: mdl-2519370
We studied genetic polymorphism of isoniazid acetylation in 47 tuberculous patients treated with 4 drugs between Aug 1987 and Dec 1988. Inactivation of isoniazid was estimated from urine samples after administration of the drug (10 mg/kg). There were 18 slow and 29 fast acetylators. The frequency of the slow mutant gene was estimated at 0.612, which is intermediate between values found in american natives (0.46) and western europeans (0.73). No associations of the presence of slow gene with sex, ABO group, ancestors, socioeconomic level, undernutrition, alcoholism or tobacco consumption were found.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Tuberculose Pulmonar
/
Isoniazida
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
Chile