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68Ga-DOTATATE PET/CT, 99mTc-HYNIC-octreotide SPECT/CT, and whole-body MR imaging in detection of neuroendocrine tumors: a prospective trial.
Etchebehere, Elba Cristina Sá de Camargo; de Oliveira Santos, Allan; Gumz, Brenda; Vicente, Andreia; Hoff, Paulo Ghem; Corradi, Gustavo; Ichiki, Wilson André; de Almeida Filho, José Geraldo; Cantoni, Saulo; Camargo, Edwaldo Eduardo; Costa, Frederico Perego.
Afiliação
  • Etchebehere EC; Division of Nuclear Medicine and PET/CT, Sirio Libanes Hospital, São Paulo, Brazil.
  • de Oliveira Santos A; Division of Nuclear Medicine and PET/CT, Sirio Libanes Hospital, São Paulo, Brazil.
  • Gumz B; Oncology Center, Sirio Libanes Hospital, São Paulo, Brazil; and.
  • Vicente A; Division of Nuclear Medicine and PET/CT, Sirio Libanes Hospital, São Paulo, Brazil.
  • Hoff PG; Oncology Center, Sirio Libanes Hospital, São Paulo, Brazil; and.
  • Corradi G; Division of Radiology, Sirio Libanes Hospital, São Paulo, Brazil.
  • Ichiki WA; Division of Nuclear Medicine and PET/CT, Sirio Libanes Hospital, São Paulo, Brazil.
  • de Almeida Filho JG; Division of Nuclear Medicine and PET/CT, Sirio Libanes Hospital, São Paulo, Brazil.
  • Cantoni S; Division of Radiology, Sirio Libanes Hospital, São Paulo, Brazil.
  • Camargo EE; Division of Nuclear Medicine and PET/CT, Sirio Libanes Hospital, São Paulo, Brazil elba.etchebehere@hsl.org.br.
  • Costa FP; Oncology Center, Sirio Libanes Hospital, São Paulo, Brazil; and.
J Nucl Med ; 55(10): 1598-604, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25168627
UNLABELLED: There are different metabolic imaging methods, various tracers, and emerging anatomic modalities to stage neuroendocrine tumor (NET). We aimed to compare NET lesion detectability among (99m)Tc-hydrazinonicotinamide (HYNIC)-octreotide (somatostatin receptor scintigraphy [SSRS]) SPECT/CT, (68)Ga-DOTATATE PET/CT, and whole-body diffusion-weighted MR imaging (WB DWI). METHODS: Nineteen consecutive patients (34-77 y old; mean, 54.3 ± 10.4 y old; 10 men and 9 women) underwent SSRS SPECT/CT, (68)Ga-DOTATATE PET/CT, and WB DWI. Images were acquired with a maximum interval of 3 mo between them and were analyzed with masking by separate teams. Planar whole-body imaging and SPECT/CT were performed from thorax to pelvis using a double-head 16-slice SPECT/CT scanner 4 h after injection of 111-185 MBq of (99m)Tc-HYNIC-octreotide. (68)Ga-DOTATATE PET/CT was performed from head to feet using a 16-slice PET/CT scanner 45 min after injection of 185 MBq of tracer. WB DWI was performed in the coronal plane using a 1.5-T scanner and a body coil. The standard method of reference for evaluation of image performance was undertaken: consensus among investigators at the end of the study, clinical and imaging follow-up, and biopsy of suggestive lesions. RESULTS: McNemar testing was applied to evaluate the detectability of lesions using (68)Ga-DOTATATE PET/CT in comparison to SSRS SPECT/CT and WB DWI: a significant difference in detectability was noted for pancreas (P = 0.0455 and P = 0.0455, respectively), gastrointestinal tract (P = 0.0455 and P = 0.0455), and bones (P = 0.0082 and P = 0.0082). Two unknown primary lesions were identified solely by (68)Ga-DOTATATE PET/CT. (68)Ga-DOTATATE PET/CT, SSRS SPECT/CT, and WB DWI demonstrated, respectively, sensitivities of 0.96, 0.60, and 0.72; specificities of 0.97, 0.99, and 1.00; positive predictive values of 0.94, 0.96, and 1.00; negative predictive values of 0.98, 0.83, and 0.88; and accuracies of 0.97, 0.86, and 0.91. CONCLUSION: (68)Ga PET/CT seems to be more sensitive for detection of well-differentiated NET lesions, especially for bone and unknown primary lesions. NET can be staged with (68)Ga-DOTATATE PET/CT. WB DWI is an efficient new method with high accuracy and without ionizing radiation exposure. SSRS SPECT/CT should be used only when (68)Ga-DOTATATE PET/CT and WB DWI are not available.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomografia Computadorizada por Raios X / Tumores Neuroendócrinos / Tomografia por Emissão de Pósitrons / Imagem Corporal Total Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Med Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tomografia Computadorizada por Raios X / Tumores Neuroendócrinos / Tomografia por Emissão de Pósitrons / Imagem Corporal Total Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Med Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos