DNA damage in Wistar rats exposed to dithiocarbamate pesticide mancozeb.
Folia Biol (Praha)
; 60(4): 202-4, 2014.
Article
em En
| MEDLINE
| ID: mdl-25152054
Pesticides are used in large amounts in agriculture and the evaluation of their toxic effects is of major concern to public and environmental health. The aim of the present study was to investigate the genotoxic potential of a commercial formulation of the fungicide mancozeb by the micronucleus test in bone marrow and the comet assay in total blood of Wistar rats. Adult male Wistar rats were treated with a solution of mancozeb at a concentration of 40 mg/kg/day, administered intraperitoneally for 18 consecutive days, and compared to a control group. The results indicate that mancozeb induced significantly higher DNA damage as detected by the comet assay and increased the frequency of micronuclei. The results show that mancozeb is genotoxic and may adversely affect the DNA integrity of exposed organisms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zineb
/
Dano ao DNA
/
Ditiocarb
/
Maneb
Limite:
Animals
Idioma:
En
Revista:
Folia Biol (Praha)
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
República Tcheca