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DNA damage in Wistar rats exposed to dithiocarbamate pesticide mancozeb.
Goldoni, A; Klauck, C R; Da Silva, S T; Da Silva, M D; Ardenghi, P G; Da Silva, L B.
Afiliação
  • Goldoni A; Research Group on Environmental Quality Indicators, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Klauck CR; Research Group on Environmental Quality Indicators, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Da Silva ST; Research Group on Human Health and Environment, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Da Silva MD; Research Group on Human Health and Environment, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Ardenghi PG; Research Group on Human Health and Environment, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Da Silva LB; Research Group on Environmental Quality Indicators, Universidade Feevale, Novo Hamburgo, RS, Brazil.
Folia Biol (Praha) ; 60(4): 202-4, 2014.
Article em En | MEDLINE | ID: mdl-25152054
Pesticides are used in large amounts in agriculture and the evaluation of their toxic effects is of major concern to public and environmental health. The aim of the present study was to investigate the genotoxic potential of a commercial formulation of the fungicide mancozeb by the micronucleus test in bone marrow and the comet assay in total blood of Wistar rats. Adult male Wistar rats were treated with a solution of mancozeb at a concentration of 40 mg/kg/day, administered intraperitoneally for 18 consecutive days, and compared to a control group. The results indicate that mancozeb induced significantly higher DNA damage as detected by the comet assay and increased the frequency of micronuclei. The results show that mancozeb is genotoxic and may adversely affect the DNA integrity of exposed organisms.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zineb / Dano ao DNA / Ditiocarb / Maneb Limite: Animals Idioma: En Revista: Folia Biol (Praha) Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: República Tcheca
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zineb / Dano ao DNA / Ditiocarb / Maneb Limite: Animals Idioma: En Revista: Folia Biol (Praha) Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: República Tcheca