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Prevalence of human papillomavirus infection and phylogenetic analysis of HPV-16 E6 variants among infected women from Northern Brazil.
Tamegão-Lopes, Bruna Pedroso; Sousa-Júnior, Edivaldo Costa; Passetti, Fabio; Ferreira, Carlos Gil; de Mello, Wyller Alencar; Duarte Silvestre, Rodrigo Vellasco.
Afiliação
  • Tamegão-Lopes BP; Laboratório de Papilomavírus, Seção de virologia, Instituto Evandro Chagas, Rodovia BR 316 km 07, Ananindeua, Pará, Brazil.
  • Sousa-Júnior EC; Laboratório de Papilomavírus, Seção de virologia, Instituto Evandro Chagas, Rodovia BR 316 km 07, Ananindeua, Pará, Brazil.
  • Passetti F; Instituto Nacional de Câncer (INCA), Clinical Research Coordination, Rua André Cavalcanti, 37, 20231-050 Rio de Janeiro, RJ, Brazil.
  • Ferreira CG; Instituto Nacional de Câncer (INCA), Clinical Research Coordination, Rua André Cavalcanti, 37, 20231-050 Rio de Janeiro, RJ, Brazil.
  • de Mello WA; Laboratório de Papilomavírus, Seção de virologia, Instituto Evandro Chagas, Rodovia BR 316 km 07, Ananindeua, Pará, Brazil.
  • Duarte Silvestre RV; Laboratório de Papilomavírus, Seção de virologia, Instituto Evandro Chagas, Rodovia BR 316 km 07, Ananindeua, Pará, Brazil.
Infect Agent Cancer ; 9: 25, 2014.
Article em En | MEDLINE | ID: mdl-25143783
BACKGROUND: The main cause of cervical cancer in the world is high risks human papillomavirus infection (mainly represented by HPV-16 and HPV-18), that are associated to the development of malign transformation of the epithelium. HPV prevalence exhibits a wide geographical variability and HPV-16 variants have been related to an increased risk of developing cervical intraepithelial lesion. The aim of this study was to describe DNA-HPV prevalence and HPV-16 variants among a women population from Northern Brazil. METHODS: One hundred and forty three women, during routine cervical cancer screening, at Juruti Project, fulfilled an epidemiological inquiry and were screened through a molecular HPV test. HPV-16 variants were determined by sequencing the HPV-16 E6 open reading frame. RESULTS: Forty two samples were considered HPV positive (29.4%). None of those had abnormal cytology results. HPV prevalence varied between different age groups (Z(U) = 14.62; p = <0.0001) and high-risk HPVs were more frequent among younger ages. The most prevalent type was HPV-16 (14%) and it variants were classified, predominantly, as European (87.5%). CONCLUSIONS: HPV prevalence in our population was higher than described by others and the most prevalent HPV types were high-risk HPVs. The European HPV-16 variant was the most prevalent among HPV-16 positive samples. Our study reinforces the fact that women with normal cytology and a positive molecular test for high-risk HPVs should be submitted to continuous follow up, in order to verify persistence of infection, promoting an early diagnosis of cervical cancer and/or its precursors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies / Screening_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Infect Agent Cancer Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prevalence_studies / Risk_factors_studies / Screening_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Infect Agent Cancer Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido