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Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner.
Nordgren, Johan; Sharma, Sumit; Bucardo, Filemon; Nasir, Waqas; Günaydin, Gökçe; Ouermi, Djeneba; Nitiema, Leon W; Becker-Dreps, Sylvia; Simpore, Jacques; Hammarström, Lennart; Larson, Göran; Svensson, Lennart.
Afiliação
  • Nordgren J; Division of Molecular Virology, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, Sweden.
  • Sharma S; Division of Molecular Virology, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, Sweden.
  • Bucardo F; Department of Microbiology, University of León, Nicaragua.
  • Nasir W; Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg.
  • Günaydin G; Department of Laboratory Medicine, Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Ouermi D; Centre de Recherche Biomoléculaire Pietro Annigoni Saint Camille CERBA/LABIOGENE, Université de Ouagadougou, Burkina Faso.
  • Nitiema LW; Centre de Recherche Biomoléculaire Pietro Annigoni Saint Camille CERBA/LABIOGENE, Université de Ouagadougou, Burkina Faso.
  • Becker-Dreps S; Department of Family Medicine, School of Medicine, University of North Carolina at Chapel Hill.
  • Simpore J; Centre de Recherche Biomoléculaire Pietro Annigoni Saint Camille CERBA/LABIOGENE, Université de Ouagadougou, Burkina Faso.
  • Hammarström L; Department of Laboratory Medicine, Division of Clinical Immunology and Transfusion Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Larson G; Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg.
  • Svensson L; Division of Molecular Virology, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, Sweden.
Clin Infect Dis ; 59(11): 1567-73, 2014 Dec 01.
Article em En | MEDLINE | ID: mdl-25097083
BACKGROUND: The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histo-blood group antigens (HBGAs) in an RV genotype-dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit susceptibility to certain RV genotypes, plausibly leading to reduced vaccine efficacy. METHODS: Association between HBGAs status and susceptibility to RV P genotypes was investigated in children in Burkina Faso and Nicaragua. In total, 242 children with diarrhea in Burkina Faso and Nicaragua were investigated, 93 of whom were RV positive. RESULTS: In Burkina Faso, the P[8] RV strains (n = 27) infected only Lewis- and secretor-positive children (27/27; P < .0001), but no Lewis-negative children. In contrast, the P[6] strains (n = 27) infected predominantly Lewis-negative children (n = 18; P < .0001) but also Lewis-positive children, irrespective of their secretor status. The results from Nicaragua confirmed that all P[8]-infected children (n = 22) were secretor Lewis positive. CONCLUSIONS: As VP4 of genotype P[8] is a component of current RV vaccines, our finding that Lewis-negative children are resistant to P[8] strains provides a plausible explanation for the reduced vaccine efficacy in populations with a high percentage of Lewis-negative individuals, such as in Africa. Furthermore, our findings provide a plausible explanation as to why P[6] RV strains are more common in Africa.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Sistema ABO de Grupos Sanguíneos / Rotavirus / Antígenos do Grupo Sanguíneo de Lewis Tipo de estudo: Risk_factors_studies Limite: Child, preschool / Humans / Infant / Newborn País/Região como assunto: Africa / America central / Nicaragua Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Suécia País de publicação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Rotavirus / Sistema ABO de Grupos Sanguíneos / Rotavirus / Antígenos do Grupo Sanguíneo de Lewis Tipo de estudo: Risk_factors_studies Limite: Child, preschool / Humans / Infant / Newborn País/Região como assunto: Africa / America central / Nicaragua Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Suécia País de publicação: Estados Unidos