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Pilot study testing the effect of physical training over the myocardial perfusion and quality of life in patients with primary microvascular angina.
de Carvalho, Eduardo Elias Vieira; Santi, Giovani Luiz; Crescêncio, Júlio César; de Oliveira, Luciano Fonseca Lemos; dos Reis, Daniela Caetano Costa; Figueiredo, Alexandre Baldini; Pintya, Antonio Osvaldo; Lima-Filho, Moyses Oliveira; Gallo-Júnior, Lourenço; Marin-Neto, José Antonio; Simões, Marcus Vinícius.
Afiliação
  • de Carvalho EE; Cardiology Division, Internal Medicine Department, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
J Nucl Cardiol ; 22(1): 130-7, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25080872
BACKGROUND: Primary microvascular angina (PMA) is a common clinical condition associated to negative impact on quality of life (QOL) and reduced physical capacity. This study aimed at evaluating the effects of aerobic physical training (APT) on myocardial perfusion, physical capacity, and QOL in patients with PMA. METHODS: We investigated 12 patients (53.8 ± 9.7 years old; 7 women) with PMA, characterized by angina, angiographycally normal coronary arteries, and reversible perfusion defects (RPDs) detected on (99m)Tc-sestamibi-SPECT myocardial perfusion scintigraphy (MPS). At baseline and after 4 month of APT, the patients underwent MPS, cardiopulmonary test, and QOL questionnaire. Stress-rest MPS images were visually analyzed by attributing semi-quantitative scores (0 = normal; 4 = absent uptake), using a 17-segment left ventricular model. Summed stress, rest, and difference scores (SDS) were calculated. RESULTS: In comparison to the baseline, in the post-training we observed a significant increase in peak-VO2 (19.4 ± 4.8 and 22.1 ± 6.2 mL·kg(-1)·minute(-1), respectively, P = .01), reduction of SDS (10.1 ± 8.8 and 2.8 ± 4.9, P = .008), and improvement in QOL scores. CONCLUSIONS: Physical training in patients with PMA is associated with reduction of myocardial perfusion abnormalities, increasing of physical capacity, and improvement in QOL. The findings of this hypothesis-generating study suggest that APT can be a valid therapeutic option for patients with PMA.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angina Microvascular / Imagem de Perfusão do Miocárdio Tipo de estudo: Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Assunto da revista: CARDIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angina Microvascular / Imagem de Perfusão do Miocárdio Tipo de estudo: Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Assunto da revista: CARDIOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos