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Inhibition of COX-2 and PGE2 in LPS-stimulated RAW264.7 cells by lonimacranthoide VI, a chlorogenic acid ester saponin.
Guan, Fuqin; Wang, Haiting; Shan, Yu; Chen, Yu; Wang, Ming; Wang, Qizhi; Yin, Min; Zhao, Youyi; Feng, Xu; Zhang, Jianhua.
Afiliação
  • Guan F; Jiangsu Key Laboratory for Bioresources of Saline Soils, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen, Nanjing, Jiangsu 210014, P.R. China ; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R.
  • Wang H; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Shan Y; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Chen Y; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Wang M; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Wang Q; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Yin M; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Zhao Y; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
  • Feng X; Jiangsu Key Laboratory for Bioresources of Saline Soils, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen, Nanjing, Jiangsu 210014, P.R. China ; College of Life Science, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R.
  • Zhang J; Jiangsu Key Laboratory for Bioresources of Saline Soils, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Memorial Sun Yat-Sen, Nanjing, Jiangsu 210014, P.R. China.
Biomed Rep ; 2(5): 760-764, 2014 Sep.
Article em En | MEDLINE | ID: mdl-25054024
Lonimacranthoide VI, first isolated from the flower buds of Lonicera macranthoides in our previous study, is a rare chlorogenic acid ester acylated at C-23 of hederagenin. In the present study, the anti-inflammatory effects of lonimacranthoide VI were studied. Lipopolysaccharides (LPS) induced an inflammatory response through the production of prostaglandin E2 (PGE2), and these levels were reduced when lonimacranthoide VI was pre-administered. Additionally, the mechanism of the anti-inflammatory effects of lonimacranthoide VI was investigated by measuring cyclooxygenase (COX) activity and mRNA expression. The results showed that lonimacranthoide VI inhibited mRNA expression and in vitro activity of COX-2 in a dose-dependent manner, whereas only the higher lonimacranthoide VI concentration possibly reduced COX-1 expression and in vitro activity. Taken together, these results indicate that lonimacranthoide VI is an important anti-inflammatory constituent of Lonicera macranthoides and that the anti-inflammatory effect is attributed to the inhibition of PGE2 production through COX activity and mRNA expression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Rep Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biomed Rep Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido