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Low dose propranolol decreases orthodontic movement.
de Oliveira, Erika Lira; Freitas, Fabiana Furtado; de Macedo, Cristina Gomes; Clemente-Napimoga, Juliana Trindade; Silva, Milena Bortolotto Felippe; Manhães, Luiz Roberto Coutinho; Junqueira, José Luiz Cintra; Napimoga, Marcelo Henrique.
Afiliação
  • de Oliveira EL; Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Dental School and Research Center, Campinas/SP, Brazil.
  • Freitas FF; Laboratory of Orofacial Pain, Department of Physiology, Piracicaba Dental School, State University of Campinas, Piracicaba/SP, Brazil.
  • de Macedo CG; Laboratory of Orofacial Pain, Department of Physiology, Piracicaba Dental School, State University of Campinas, Piracicaba/SP, Brazil.
  • Clemente-Napimoga JT; Laboratory of Orofacial Pain, Department of Physiology, Piracicaba Dental School, State University of Campinas, Piracicaba/SP, Brazil.
  • Silva MB; Laboratory of Oral Radiology, São Leopoldo Mandic Dental School and Research Center, Campinas/SP, Brazil.
  • Manhães LR; Laboratory of Oral Radiology, São Leopoldo Mandic Dental School and Research Center, Campinas/SP, Brazil.
  • Junqueira JL; Laboratory of Oral Radiology, São Leopoldo Mandic Dental School and Research Center, Campinas/SP, Brazil.
  • Napimoga MH; Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Dental School and Research Center, Campinas/SP, Brazil. Electronic address: napimogamh@yahoo.com.
Arch Oral Biol ; 59(10): 1094-100, 2014 10.
Article em En | MEDLINE | ID: mdl-25033380
OBJECTIVE: Low dose propranolol has previously been demonstrated to suppress bone remodelling. Therefore, its effect on orthodontic movement was tested. DESIGN: Rats were assigned as follows (n=5): animals with no orthodontic appliance (G1); the remaining groups were fitted with a Ni-Ti closed-coil spring ligated to the upper left first molar and connected to the incisors using metal and resin and received vehicle only (G2), 0.1mg/kg (G3) or 20mg/kg (G4) of propranolol orally. Cone Beam Computed Tomography was performed using high resolution for image capture. The distance between the first and second upper molars, both with and without the orthodontic appliance, was measured in millimetres. Gingival tissue was harvested and assessed for IL-1ß and IL-6 using ELISA and for ICAM-1 and RANKL by Western blotting. RESULTS: The orthodontic appliance induced a significant tooth movement in G2 when compared to the animals without an orthodontic appliance (G1) (p<0.05). The animals from G3 showed a significantly reduction in tooth movement (p<0.05) when compared with rats from G2. Animals treated with 20mg/kg of propranolol (G4) showed tooth movement similar to that of G2. The reduced tooth movement observed in the animals treated with 0.1mg/kg of propranolol (G3) occurred due to decreased amounts of IL-1ß and IL-6, in addition to lower ICAM-1 and RANKL expression. CONCLUSIONS: Low dose propranolol inhibits bone remodelling and orthodontic movement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propranolol / Técnicas de Movimentação Dentária Limite: Animals Idioma: En Revista: Arch Oral Biol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propranolol / Técnicas de Movimentação Dentária Limite: Animals Idioma: En Revista: Arch Oral Biol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido