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Diets rich in saturated and polyunsaturated fatty acids induce morphological alterations in the rat ventral prostate.
Furriel, Angélica; Campos-Silva, Pamella; Silva, Paola Cariello Guedes Picarote; Costa, Waldemar Silva; Sampaio, Francisco José Barcellos; Gregório, Bianca Martins.
Afiliação
  • Furriel A; Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
  • Campos-Silva P; Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
  • Silva PC; Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
  • Costa WS; Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
  • Sampaio FJ; Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
  • Gregório BM; Department of Anatomy, State University of Rio de Janeiro, Urogenital Research Unit, Biomedical Center, Rio de Janeiro, Brazil.
PLoS One ; 9(7): e102876, 2014.
Article em En | MEDLINE | ID: mdl-25029463
AIM: To evaluate the influence of dietary lipid quality on the body mass, carbohydrate metabolism and morphology of the rat ventral prostate. MATERIALS AND METHODS: Wistar rats were divided into four groups: SC (standard chow), HF-S (high-fat diet rich in saturated fatty acids), HF-P (high-fat diet rich in polyunsaturated fatty acids) and HF-SP (high-fat diet rich in saturated and polyunsaturated fatty acids). We analyzed body mass, fat mass deposits, plasma blood, insulin resistance and the ventral prostate structure. RESULTS: Groups that received high-fat diets were heavier and presented larger fat deposits than SC group. The HF-S and HF-SP groups had higher glucose, insulin and total cholesterol serum levels and insulin resistance compared with the SC. The acinar area, epithelium height and area density of the lumen were higher in the HF-SP than in the other groups. The epithelium area density and epithelial cell proliferation were greater in the HF-P and HF-SP than in the SC group. All of the groups that received high-fat diets had greater area density of the stroma, area density of smooth muscle cells and stromal cell proliferation compared with the SC group. CONCLUSION: Diets rich in saturated and/or polyunsaturated fatty acids induced overweight. Independently of insulin resistance, polyunsaturated fatty acids increased prostate stromal and epithelial cell proliferation. Saturated fatty acids influenced only stromal cellular proliferation. These structural and morphometric alterations may be considered risk factors for the development of adverse remodeling process in the rat ventral prostate.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Gorduras na Dieta / Ácidos Graxos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Próstata / Gorduras na Dieta / Ácidos Graxos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos