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Maternal obesity, gestational weight gain, and offspring adiposity: the exploring perinatal outcomes among children study.
Kaar, Jill L; Crume, Tessa; Brinton, John T; Bischoff, Kimberly J; McDuffie, Robert; Dabelea, Dana.
Afiliação
  • Kaar JL; Department of Pediatrics, Colorado School of Medicine, University of Colorado Denver, Denver, CO. Electronic address: Jill.Kaar@ucdenver.edu.
  • Crume T; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO.
  • Brinton JT; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Denver, Denver, CO.
  • Bischoff KJ; Institute for Health Research, Kaiser Permanente of Colorado, Denver, CO.
  • McDuffie R; Department of Perinatology, Kaiser Permanente of Colorado, Denver, CO.
  • Dabelea D; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO.
J Pediatr ; 165(3): 509-15, 2014 Sep.
Article em En | MEDLINE | ID: mdl-24996985
OBJECTIVE: To determine whether adequate vs excessive gestational weight gain (GWG) attenuated the association between maternal obesity and offspring outcomes. STUDY DESIGN: Data from 313 mother-child pairs participating in the Exploring Perinatal Outcomes among Children study were used to test this hypothesis. Maternal prepregnancy body mass index (BMI) and weight measures throughout pregnancy were abstracted from electronic medical records. GWG was categorized according to the 2009 Institute of Medicine criteria as adequate or excessive. Offspring outcomes were obtained at a research visit (average age 10.4 years) and included BMI, waist circumference (WC), subcutaneous adipose tissue (SAT) and visceral adipose tissue, high-density lipoprotein cholesterol, and triglyceride levels. RESULTS: More overweight/obese mothers exceeded the Institute of Medicine GWG recommendations (68%) compared with normal-weight women (50%) (P < .01). Maternal prepregnancy BMI was associated with worse childhood outcomes, particularly among offspring of mothers with excessive GWG (increased BMI [20.34 vs 17.80 kg/m(2)], WC [69.23 vs 62.83 cm], SAT [149.30 vs 90.47 cm(2)], visceral adipose tissue [24.11 vs 17.55 cm(2)], and homeostatic model assessment [52.52 vs 36.69], all P < .001). The effect of maternal prepregnancy BMI on several childhood outcomes was attenuated for offspring of mothers with adequate vs excessive GWG (P < .05 for the interaction between maternal BMI and GWG status on childhood BMI, WC, SAT, and high-density lipoprotein cholesterol). CONCLUSION: Our findings lend support for pregnancy interventions aiming at controlling GWG to prevent childhood obesity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Aumento de Peso / Gordura Subcutânea / Obesidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Aumento de Peso / Gordura Subcutânea / Obesidade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Child / Female / Humans / Male / Pregnancy Idioma: En Revista: J Pediatr Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos