Telomere dysfunction and hematologic disorders.

Paiva, Raquel M A; Calado, Rodrigo T

Paiva, Raquel M A; Calado, Rodrigo T.

Afiliação

Paiva RM; Department of Internal Medicine, University of São Paulo at Ribeirão Preto School of Medicine, Ribeirão Preto, São Paulo, Brazil.
Calado RT; Department of Internal Medicine, University of São Paulo at Ribeirão Preto School of Medicine, Ribeirão Preto, São Paulo, Brazil.

Prog Mol Biol Transl Sci ; 125: 133-57, 2014.

Article em En | MEDLINE | ID: mdl-24993701

RESUMO

Aplastic anemia is a disease in which the hematopoietic stem cell fails to adequately produce peripheral blood cells, causing pancytopenia. In some cases of acquired aplastic anemia and in inherited type of aplastic anemia, dyskeratosis congenita, telomere biology gene mutations and telomere shortening are etiologic. Telomere erosion hampers the ability of hematopoietic stem and progenitor cells to adequately replicate, clinically resulting in bone marrow failure. Additionally, telomerase mutations and short telomeres are genetic risk factors for the development of some hematologic cancers, including myelodysplastic syndrome, acute myeloid leukemia, and chronic lymphocytic leukemia.

Assuntos

Doenças Hematológicas/genética; Doenças Hematológicas/patologia; Telômero/patologia; Animais; Humanos; Telomerase/metabolismo; Telômero/genética; Telômero/metabolismo

Palavras-chave

Aplastic anemia; Bone marrow failure; Dyskeratosis congenita; Leukemia; Myelodysplastic syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telômero / Doenças Hematológicas Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Prog Mol Biol Transl Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

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