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Hepatitis B virus infection in Latin America: a genomic medicine approach.
Roman, Sonia; Jose-Abrego, Alexis; Fierro, Nora Alma; Escobedo-Melendez, Griselda; Ojeda-Granados, Claudia; Martinez-Lopez, Erika; Panduro, Arturo.
Afiliação
  • Roman S; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
  • Jose-Abrego A; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
  • Fierro NA; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
  • Escobedo-Melendez G; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
  • Ojeda-Granados C; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
  • Martinez-Lopez E; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
  • Panduro A; Sonia Roman, Alexis Jose-Abrego, Claudia Ojeda-Granados, Erika Martinez-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara "Fray Antonio Alcalde" and University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
World J Gastroenterol ; 20(23): 7181-96, 2014 Jun 21.
Article em En | MEDLINE | ID: mdl-24966588
Hepatitis B virus (HBV) infection is the leading cause of severe chronic liver disease. This article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin America. Three levels of evolutionary adaptation may correlate with the clinical outcomes of HBV infection. Infections in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America; these strains have historically circulated among the indigenous population. Both genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South Americans. In contrast, genotypes F, A and D are common in acute and chronic infections among mestizos with Caucasian ancestry. Hepatocellular carcinoma is rare in Mexicans, but it has been associated with genotype F1b among Argentineans. This observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America, which contrast with those reported in other regions of the world.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Genômica / Hepatite B Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: World J Gastroenterol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Genômica / Hepatite B Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: World J Gastroenterol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos