Detection of sickle cell hemoglobin in Haiti by genotyping and hemoglobin solubility tests.
Am J Trop Med Hyg
; 91(2): 406-11, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24957539
Sickle cell disease is a growing global health concern because infants born with the disorder in developing countries are now surviving longer with little access to diagnostic and management options. In Haiti, the current state of sickle cell disease/trait in the population is unclear. To inform future screening efforts in Haiti, we assayed sickle hemoglobin mutations using traditional hemoglobin solubility tests (HST) and add-on techniques, which incorporated spectrophotometry and insoluble hemoglobin separation. We also generated genotype data as a metric for HST performance. We found 19 of 202 individuals screened with HST were positive for sickle hemoglobin, five of whom did not carry the HbS allele. We show that spectrophotometry and insoluble hemoglobin separation add-on techniques could resolve false positives associated with the traditional HST approach, with some limitations. We also discuss the incorporation of insoluble hemoglobin separation observation with HST in suboptimal screening settings like Haiti.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobina Falciforme
/
Genótipo
/
Anemia Falciforme
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
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Aged80
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Child
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Child, preschool
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Humans
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Infant
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Middle aged
País/Região como assunto:
Haiti
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
Estados Unidos