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A single genus in the gut microbiome reflects host preference and specificity.
Eren, A Murat; Sogin, Mitchell L; Morrison, Hilary G; Vineis, Joseph H; Fisher, Jenny C; Newton, Ryan J; McLellan, Sandra L.
Afiliação
  • Eren AM; Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA.
  • Sogin ML; Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA.
  • Morrison HG; Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA.
  • Vineis JH; Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA.
  • Fisher JC; School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Newton RJ; School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • McLellan SL; School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
ISME J ; 9(1): 90-100, 2015 Jan.
Article em En | MEDLINE | ID: mdl-24936765
Delineating differences in gut microbiomes of human and animal hosts contributes towards understanding human health and enables new strategies for detecting reservoirs of waterborne human pathogens. We focused upon Blautia, a single microbial genus that is important for nutrient assimilation as preliminary work suggested host-related patterns within members of this genus. In our dataset of 57 M sequence reads of the V6 region of the 16S ribosomal RNA gene in samples collected from seven host species, we identified 200 high-resolution taxonomic units within Blautia using oligotyping. Our analysis revealed 13 host-specific oligotypes that occurred exclusively in fecal samples of humans (three oligotypes), swine (six oligotypes), cows (one oligotype), deer (one oligotype), or chickens (two oligotypes). We identified an additional 171 oligotypes that exhibited differential abundance patterns among all the host species. Blautia oligotypes in the human population obtained from sewage and fecal samples displayed remarkable continuity. Oligotypes from only 10 Brazilian human fecal samples collected from individuals in a rural village encompassed 97% of all Blautia oligotypes found in a Brazilian sewage sample from a city of three million people. Further, 75% of the oligotypes in Brazilian human fecal samples matched those in US sewage samples, implying that a universal set of Blautia strains may be shared among culturally and geographically distinct human populations. Such strains can serve as universal markers to assess human fecal contamination in environmental samples. Our results indicate that host-specificity and host-preference patterns of organisms within this genus are driven by host physiology more than dietary habits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trato Gastrointestinal / Especificidade de Hospedeiro / Microbiota / Bactérias Gram-Positivas Aspecto: Patient_preference Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: ISME J Assunto da revista: MICROBIOLOGIA / SAUDE AMBIENTAL Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trato Gastrointestinal / Especificidade de Hospedeiro / Microbiota / Bactérias Gram-Positivas Aspecto: Patient_preference Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: ISME J Assunto da revista: MICROBIOLOGIA / SAUDE AMBIENTAL Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido