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Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients.
Farsi, Payam Farahbakhsh; Djazayery, Abolghassem; Eshraghian, Mohammad Reza; Koohdani, Fariba; Saboor-Yaraghi, Ali Akbar; Derakhshanian, Hoda; Zarei, Mahnaz; Javanbakht, Mohammad Hassan; Djalali, Mahmoud.
Afiliação
  • Farsi PF; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Djazayery A; Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Eshraghian MR; Department of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Koohdani F; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Saboor-Yaraghi AA; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Derakhshanian H; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Zarei M; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Javanbakht MH; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
  • Djalali M; Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Arq Bras Endocrinol Metabol ; 58(4): 335-40, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24936727
OBJECTIVE: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. SUBJECTS AND METHODS: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. RESULTS: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). CONCLUSIONS: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Ácidos Graxos Ômega-3 / Suplementos Nutricionais / Diabetes Mellitus Tipo 2 / Ácidos Graxos não Esterificados Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Bras Endocrinol Metabol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Ácidos Graxos Ômega-3 / Suplementos Nutricionais / Diabetes Mellitus Tipo 2 / Ácidos Graxos não Esterificados Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Bras Endocrinol Metabol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Irã País de publicação: Brasil