Synthesis of steroidal derivatives containing substituted, fused and spiro pyrazolines.
Steroids
; 87: 86-92, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24928724
An efficient and facile synthesis of fused, substituted and spiro pyrazoline steroid derivatives through a cycloaddition reaction of different α,ß-unsaturated ketones with hydrazine acetate in acetic acid is reported. Depending on the starting material, the ring closure reaction provided a mixture of two steroidal pyrazoline epimers that were separated and studied by NMR techniques. In one case it was possible to isolate and characterize the hydrazone derivative as the reaction intermediate, which confirms the mechanism proposed in the literature [11,25,26].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Compostos de Espiro
/
Esteroides
Idioma:
En
Revista:
Steroids
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Estados Unidos