Cross-sectional study of genital carcinogenic HPV infections in Paramaribo, Suriname: prevalence and determinants in an ethnically diverse population of women in a pre-vaccination era.

Geraets, Daan T; Grünberg, Antoon W; van der Helm, Jannie J; Schim van der Loeff, Maarten F; Quint, Koen D; Sabajo, Leslie O A; de Vries, Henry J C

Geraets, Daan T; Grünberg, Antoon W; van der Helm, Jannie J; Schim van der Loeff, Maarten F; Quint, Koen D; Sabajo, Leslie O A; de Vries, Henry J C.

Afiliação

Geraets DT; DDL Diagnostic Laboratory, Rijswijk, The Netherlands.
Grünberg AW; Department of Public Health, Ministry of Health, Paramaribo, Suriname.
van der Helm JJ; STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, The Netherlands Department of Research, Public Health Service Amsterdam, Amsterdam, The Netherlands.
Schim van der Loeff MF; Department of Research, Public Health Service Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Quint KD; DDL Diagnostic Laboratory, Rijswijk, The Netherlands Department of Dermatology LUMC, University of Leiden, Leiden, The Netherlands.
Sabajo LO; Dermatological Service, Ministry of Health, Paramaribo, Suriname.
de Vries HJ; STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Env

Sex Transm Infect ; 90(8): 627-33, 2014 Dec.

Article em En | MEDLINE | ID: mdl-24920666

RESUMO

OBJECTIVE: Cervical cancer is caused by carcinogenic human papillomavirus (HPV) infections. Prior to the introduction of HPV vaccination in Suriname, we performed a cross-sectional study to estimate the prevalence of and determinants for genital carcinogenic HPV infections. METHODS: Women were recruited at a family planning (FP) clinic and a sexually transmitted infections (STI) clinic. Vaginal swabs were used for HPV genotyping by the SPF10 PCR-DEIA-LiPA25 system. Logistic regression was used to identify determinants for carcinogenic HPV infection. RESULTS: The prevalence of any HPV was 54.2% and of carcinogenic HPV was 27.9% among 813 women attending the FP clinic. Among the 188 women attending the STI clinic, the prevalence of any HPV (76.1%) and of carcinogenic HPV (40.4%) was significantly higher. HPV52 was the most prevalent genotype in both clinics. The prevalence of HPV16 and/or 18 was 6.4% in the FP clinic and 12.2% in the STI clinic. The following determinants were independently associated with carcinogenic HPV infection among women visiting the FP clinic: ≥2 recent partners (OR 1.53; 95% CI 1.13 to 2.06), Chlamydia trachomatis co-infection (OR 1.89; 95% CI 1.32 to 2.70), disassortative ethnic sexual mixing (OR 1.50; 95% CI 1.13 to 1.99) and ethnic group (OR 1.90; 95% CI 1.27 to 2.85 for Creole and OR 1.67; 95% CI 1.06 to 2.62 for mixed ethnicity, both compared with Hindustani). No independent determinants were found among women visiting the STI clinic. CONCLUSIONS: Carcinogenic HPV is highly prevalent among women in Suriname, and not equally distributed among ethnic groups. These data provide a baseline to assess possible shifts in the prevalence of HPV genotypes following vaccination.

Assuntos

Papillomaviridae/classificação; Papillomaviridae/isolamento & purificação; Infecções por Papillomavirus/epidemiologia; Infecções por Papillomavirus/virologia; Adulto; Estudos Transversais; Etnicidade; Feminino; Genótipo; Técnicas de Genotipagem; Humanos; Papillomaviridae/genética; Fatores de Risco; Suriname/epidemiologia; Adulto Jovem

Palavras-chave

Cervical Neoplasia; Chlamydia Infection; Epidemiology (Clinical); HPV

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papillomaviridae / Infecções por Papillomavirus Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: America do sul / Caribe ingles / Suriname Idioma: En Revista: Sex Transm Infect Assunto da revista: DOENCAS SEXUALMENTE TRANSMISSIVEIS Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido

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