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Liver regeneration with l-glutamine supplemented diet: experimental study in rats.
Magalhães, Cibelle Ribeiro; Malafaia, Osvaldo; Torres, Orlando Jorge Martins; Moreira, Luciane Bugmann; Tefil, Silvia Carmen da Silva Gonçalves; Pinherio, Matheus da Rocha; Harada, Bruna Ayumi.
Afiliação
  • Magalhães CR; Medical Research Institute, Evangelical Faculty of Paraná, Evangelical University Hospital.
  • Malafaia O; Medical Research Institute, Evangelical Faculty of Paraná, Evangelical University Hospital.
  • Torres OJ; Department of Surgery, Universidade Federal do Maranhão, São Luís, MA, Brasil.
  • Moreira LB; Medical Research Institute, Evangelical Faculty of Paraná, Evangelical University Hospital.
  • Tefil SC; Medical Research Institute, Evangelical Faculty of Paraná, Evangelical University Hospital.
  • Pinherio Mda R; Hospital Universitário Evangélico de Curitiba, Faculdade Evangélica do Paraná, PR, Brasil.
  • Harada BA; Hospital Universitário Evangélico de Curitiba, Faculdade Evangélica do Paraná, PR, Brasil.
Rev Col Bras Cir ; 41(2): 117-21, 2014.
Article em En, Pt | MEDLINE | ID: mdl-24918725
OBJECTIVE: To assess liver regeneration in rats after 60% hepatectomy with and without supplementation of L-glutamine through liver weight changes, laboratory parameters and histological study. METHODS: 36 male rats were divided into two groups: glutamine group and control group. Each group was subdivided into three subgroups, with death in 24h, 72h and seven days. The glutamine group received water and standard diet supplemented with L-glutamine, and the control recieved 0.9% saline. In all subgroups analysis of liver regeneration was made by the Kwon formula, study of liver function (AST, ALT, GGT, total bilirubin, indirect and indirect bilirubin and albumin) and analysis of cell mitosis by hematoxylin-eosin. RESULTS: In both groups there was liver regeneration by weight gain. Gamma-GT increased significantly in the control group (p < 0.05); albumin increased in the glutamine group. The other indicators of liver function showed no significant differences. Histological analysis at 72h showed a higher number of mitoses in the glutamine group, with no differences in other subgroups. CONCLUSION: Diet supplementation with L glutamine is beneficial for liver regeneration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Suplementos Nutricionais / Glutamina / Regeneração Hepática Limite: Animals Idioma: En / Pt Revista: Rev Col Bras Cir Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Suplementos Nutricionais / Glutamina / Regeneração Hepática Limite: Animals Idioma: En / Pt Revista: Rev Col Bras Cir Ano de publicação: 2014 Tipo de documento: Article País de publicação: Brasil