Reversible posterior encephalopathy syndrome secondary to sunitinib.

Costa, Ricardo; Costa, Rubens; Costa, Renata; Junior, Gilberto Moura de Brito; Cartaxo, Henrique Queiroz; de Barros, Alex Caetano

Costa, Ricardo; Costa, Rubens; Costa, Renata; Junior, Gilberto Moura de Brito; Cartaxo, Henrique Queiroz; de Barros, Alex Caetano.

Afiliação

Costa R; Department of Oncology, Real Hospital Portugues, 52010 Recife, PE, Brazil.
Costa R; Cedar Valley Cancer Center, Waterloo, IA 50701, USA.
Costa R; American University of the Caribbean, Coral Gables, FL 33134, USA.
Junior GM; Department of Radiology, Real Hospital Portugues, 52010 Recife, PE, Brazil.
Cartaxo HQ; Department of Radiology, Real Hospital Portugues, 52010 Recife, PE, Brazil.
de Barros AC; Department of Neurosurgery, Real Hospital Portugues, 52010 Recife, PE, Brazil.

Case Rep Oncol Med ; 2014: 952624, 2014.

Article em En | MEDLINE | ID: mdl-24900933

RESUMO

Reversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Sunitinib is an inhibitor of the vascular endothelial growth factor receptor widely used in the treatment of metastatic renal cell carcinoma (RCC). We report a rare case of RPLS occurring on therapy with sunitinib in a patient with RCC. Our aim is to highlight the importance of considering RPLS as a diagnostic possibility and to hold sunitinib for RCC patients presenting with neurologic symptoms.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Case Rep Oncol Med Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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