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Genetics of Psychosis in Alzheimer Disease.
DeMichele-Sweet, Mary Ann A; Sweet, Robert A.
Afiliação
  • DeMichele-Sweet MA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.
  • Sweet RA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA ; Department of Neurology, University of Pittsburgh, Pittsburgh, PA ; VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA.
Curr Genet Med Rep ; 2(1): 30-38, 2014 Mar.
Article em En | MEDLINE | ID: mdl-24883238
Psychosis occurs in approximately half of patients with Alzheimer disease (AD with psychosis, AD+P). AD+P patients have more rapid cognitive decline, greater behavioral symptoms, and higher mortality than do AD patients without psychosis. Studies in three independent cohorts have shown that psychosis in AD aggregates in families, with estimated heritability of 29.5 - 60.8%. These findings have motivated studies to investigate and uncover the genes responsible for the development of psychosis, with the ultimate goal of identifying potential biologic mechanisms that may serve as leads to specific therapies. Linkage analyses have implicated loci on chromosomes 2, 6, 7, 8, 15, and 21 with AD+P. Association studies of APOE do not support it as a risk gene for psychosis in AD. No other candidate genes, such as neurodegenerative and monoamine genes, show conclusive evidence of association with AD+P. However, a recent genome-side association study has produced some promising leads, including among them genes that have been associated with schizophrenia. This review summarizes the current knowledge of the genetic basis of AD+P.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Curr Genet Med Rep Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Curr Genet Med Rep Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos