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Breast cancer risk after occupational solvent exposure: the influence of timing and setting.
Ekenga, Christine C; Parks, Christine G; D'Aloisio, Aimee A; DeRoo, Lisa A; Sandler, Dale P.
Afiliação
  • Ekenga CC; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway christine.ekenga@nih.go
  • Parks CG; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • D'Aloisio AA; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
  • DeRoo LA; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, NorwayAuthors' Affiliations: E
  • Sandler DP; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Cancer Res ; 74(11): 3076-83, 2014 Jun 01.
Article em En | MEDLINE | ID: mdl-24879566
Organic solvents are ubiquitous in occupational settings where they may contribute to risks for carcinogenesis. However, there is limited information on organic solvents as human breast carcinogens. We examined the relationship between occupational exposure to solvents and breast cancer in a prospective study of 47,661 women with an occupational history in the Sister Study cohort. Occupational solvent exposure was categorized using self-reported job-specific solvent use collected at baseline. Multivariable Cox regression analyses were used to assess breast cancer risk, adjusting for established breast cancer risk factors. A total of 1,798 women were diagnosed with breast cancer during follow-up, including 1,255 invasive cases. Overall the risk of invasive breast cancer was not associated with lifetime exposure to solvents [HR, 1.04; 95% confidence interval (CI), 0.88-1.24]. Parous women who worked with solvents before their first full-term birth had an increased risk of estrogen receptor-positive invasive breast cancer compared with women who never worked with solvents (HR, 1.39; 95% CI, 1.03-1.86). A significantly elevated risk for estrogen receptor-positive invasive breast cancer was associated with solvent exposure among clinical laboratory technologists and technicians (HR, 2.00; 95% CI, 1.07-3.73). Occupational exposure to solvents before first birth, a critical period of breast tissue differentiation, may result in increased vulnerability for breast cancer. Our findings suggest a need for future studies in this area to focus on exposure time windows and solvent types in different occupational settings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solventes / Neoplasias da Mama / Exposição Ocupacional / Doenças Profissionais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País/Região como assunto: America do norte / Caribe / Puerto rico Idioma: En Revista: Cancer Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Noruega País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Solventes / Neoplasias da Mama / Exposição Ocupacional / Doenças Profissionais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Middle aged País/Região como assunto: America do norte / Caribe / Puerto rico Idioma: En Revista: Cancer Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Noruega País de publicação: Estados Unidos