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The influence of HIV-1 subtypes C, CRF31_BC and B on disease progression and initial virologic response to HAART in a Southern Brazilian cohort.
Nunes, Cynara Carvalho; Matte, Maria Cristina Cotta; Dias, Claudia Fontoura; Araújo, Leonardo Augusto Luvison; Guimarães, Luciano Santos Pinto; Almeida, Sabrina; Brígido, Luis Fernando Macedo.
Afiliação
  • Nunes CC; Santa Marta Health Center, Municipal Health Department, Porto Alegre, RS, Brazil.
  • Matte MC; State Foundation for Health Research and Production, Center for Scientific and Technological Development, Porto Alegre, RS, Brazil.
  • Dias CF; Municipal Health Department, STD/AIDS Specialized Care Center, Porto Alegre, RS, Brazil.
  • Araújo LA; State Foundation for Health Research and Production, Center for Scientific and Technological Development, Porto Alegre, RS, Brazil.
  • Guimarães LS; Department of Epidemiology and Biostatistics, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • Almeida S; State Foundation for Health Research and Production, Center for Scientific and Technological Development, Porto Alegre, RS, Brazil.
  • Brígido LF; Adolfo Lutz Institute, São Paulo, SP, Brazil.
Rev Inst Med Trop Sao Paulo ; 56(3): 205-11, 2014.
Article em En | MEDLINE | ID: mdl-24878998
BACKGROUND: Although most HIV-1 infections in Brazil are due to subtype B, Southern Brazil has a high prevalence of subtype C and recombinant forms, such as CRF31_BC. This study assessed the impact of viral diversity on clinical progression in a cohort of newly diagnosed HIV-positive patients. METHODS: From July/2004 to December/2005, 135 HIV-infected patients were recruited. The partial pol region was subtyped by phylogeny. A generalized estimating equation (GEE) model was used to examine the relationship between viral subtype, CD4+ T cell count and viral load levels before antiretroviral therapy. Hazard ratio (Cox regression) was used to evaluate factors associated with viral suppression (viral load < 50 copies/mL at six months). RESULTS: Main HIV-1 subtypes included B (29.4%), C (28.2%), and CRF31_BC (23.5%). Subtypes B and C showed a similar trend in CD4+ T cell decline. Comparison of non-B (C and CRF31_BC) and B subtypes revealed no significant difference in the proportion of patients with viral suppression at six months (week 24). Higher CD4+ T cell count and lower viral load were independently associated with viral suppression. CONCLUSION: No significant differences were found between subtypes; however, lower viral load and higher CD4+ T cell count before therapy were associated with better response.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Inst Med Trop Sao Paulo Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Fármacos Anti-HIV / Terapia Antirretroviral de Alta Atividade Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Rev Inst Med Trop Sao Paulo Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil