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Early postoperative changes in hematological, erythrocyte aggregation and blood coagulation parameters after unilateral implantation of polytetrafluoroethylene vascular graft in the femoral artery of beagle dogs.
Toth, Csaba; Klarik, Zoltan; Kiss, Ferenc; Toth, Eniko; Hargitai, Zoltan; Nemeth, Norbert.
Afiliação
  • Toth C; Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
  • Klarik Z; Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
  • Kiss F; Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
  • Toth E; Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary.
  • Hargitai Z; Department of Pathology, Kenezy Hospital, University of Debrecen, Hungary.
  • Nemeth N; Institute of Surgery, Kenezy Hospital, University of Debrecen, Hungary.
Acta Cir Bras ; 29(5): 320-7, 2014 May.
Article em En | MEDLINE | ID: mdl-24863320
PURPOSE: The failure of small-caliber vascular grafts still means a serious problem. Concerning the early postoperative complications we aimed to investigate the hemostaseological and hemorheological aspects of this issue in a canine model. METHODS: In the Control group only anesthesia was induced. In the Grafted group under general anesthesia a 3.5-cm segment was resected unilaterally from the femoral artery and replaced with a PTFE graft (diameter: 3 mm). On the 1st-3rd-5th-7th and 14th postoperative days the skin temperature of both hind limbs was measured, and blood sampling occurred for hematological, hemostaseological and hemorheological tests. RESULTS: The skin temperature of the operated versus intact limbs did not differ. In the Grafted group leukocyte count was elevated by the 1st postoperative day, while platelet count increased over the entire follow-up period. Fibrinogen concentration rose on the 1st-5th days, activated partial thromboplastin time increased on the 3rd-7th days. Erythrocyte aggregation was enhanced significantly on the 1st-5th days. In specimens taken on the 14th day, histologically we found matured thrombus narrowing the graft lumen. CONCLUSIONS: Small-caliber PTFE graft implantation into the femoral artery caused significant changes in several hemostaseological and hemorheological parameters. However, better clarifying the factors leading to early thrombosis of these grafts needs further studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Politetrafluoretileno / Coagulação Sanguínea / Modelos Animais / Agregação Eritrocítica / Artéria Femoral / Enxerto Vascular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Hungria País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Politetrafluoretileno / Coagulação Sanguínea / Modelos Animais / Agregação Eritrocítica / Artéria Femoral / Enxerto Vascular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Acta Cir Bras Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Hungria País de publicação: Brasil