Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis.

Neto, João B A; da Silva, Cecília R; Neta, Maria A S; Campos, Rosana S; Siebra, Janaína T; Silva, Rose A C; Gaspar, Danielle M; Magalhães, Hemerson I F; de Moraes, Manoel O; Lobo, Marina D P; Grangeiro, Thalles B; Carvalho, Tatiane S C; Diogo, Emilay B T; da Silva Júnior, Eufrânio N; Rodrigues, Felipe A R; Cavalcanti, Bruno C; Júnior, Hélio V N

Neto, João B A; da Silva, Cecília R; Neta, Maria A S; Campos, Rosana S; Siebra, Janaína T; Silva, Rose A C; Gaspar, Danielle M; Magalhães, Hemerson I F; de Moraes, Manoel O; Lobo, Marina D P; Grangeiro, Thalles B; Carvalho, Tatiane S C; Diogo, Emilay B T; da Silva Júnior, Eufrânio N; Rodrigues, Felipe A R; Cavalcanti, Bruno C; Júnior, Hélio V N.

Afiliação

Neto JB; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
da Silva CR; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in
Neta MA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in
Campos RS; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in
Siebra JT; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Silva RA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Gaspar DM; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Magalhães HI; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pharmaceutical Sciences, Center for Toxicological Assistance, University Federal of Paraíba, Para
de Moraes MO; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Lobo MD; Department of Biology, ScienceCenter, Molecular Genetics Laboratory, Federal University of Ceará, Ceará, Brazil.
Grangeiro TB; Department of Biology, ScienceCenter, Molecular Genetics Laboratory, Federal University of Ceará, Ceará, Brazil.
Carvalho TS; Natural Products Research Nucleus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Diogo EB; Department of Chemistry, Institute of Exact Sciences, Laboratory of Synthetic and Heterocyclic Chemistry, Federal University of Minas Gerais, Minas Gerais, Brazil.
da Silva Júnior EN; Department of Chemistry, Institute of Exact Sciences, Laboratory of Synthetic and Heterocyclic Chemistry, Federal University of Minas Gerais, Minas Gerais, Brazil.
Rodrigues FA; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Cavalcanti BC; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza
Júnior HV; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in

PLoS One ; 9(5): e93698, 2014.

Article em En | MEDLINE | ID: mdl-24817320

Assuntos

Antifúngicos/farmacologia; Candida/efeitos dos fármacos; Farmacorresistência Fúngica/efeitos dos fármacos; Fluconazol/farmacologia; Naftoquinonas/farmacologia; Animais; Antifúngicos/síntese química; Antifúngicos/química; Candida/classificação; Candida/genética; Candida tropicalis/efeitos dos fármacos; Candida tropicalis/genética; Candida tropicalis/metabolismo; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Dano ao DNA; DNA Fúngico/química; DNA Fúngico/genética; DNA Fúngico/metabolismo; DNA Espaçador Ribossômico/química; DNA Espaçador Ribossômico/genética; Fibroblastos/citologia; Fibroblastos/efeitos dos fármacos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Testes de Sensibilidade Microbiana; Modelos Químicos; Dados de Sequência Molecular; Estrutura Molecular; Naftoquinonas/síntese química; Naftoquinonas/química; Fosfatidilserinas; RNA Ribossômico 5,8S/genética; Espécies Reativas de Oxigênio/metabolismo; Análise de Sequência de DNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Candida / Fluconazol / Naftoquinonas / Farmacorresistência Fúngica / Antifúngicos Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

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