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Modeling the effects of covalently closed circular DNA and dendritic cells in chronic HBV infection.
Li, Qiang; Lu, Furong; Deng, Guohong; Wang, Kaifa.
Afiliação
  • Li Q; School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, PR China; Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, PR
  • Lu F; Department of Chemistry, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, PR China.
  • Deng G; Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China. Electronic address: gh_deng@hotmail.com.
  • Wang K; School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, PR China. Electronic address: kfwang001@gmail.com.
J Theor Biol ; 357: 1-9, 2014 Sep 21.
Article em En | MEDLINE | ID: mdl-24816182
The contribution of covalently closed circular DNA (cccDNA) and dendritic cells (DCs) to the progression of chronic hepatitis B virus (HBV) infection remains largely unknown. A dynamic model with seven cell types was proposed based on the biological mechanisms of viral replication and the host immune response. The cccDNA self-amplification rate was found to be closely related to both the basic reproduction number of the virus and the immune response. The combination of the cccDNA self-amplification rate and the initial activated DC count induces rich dynamics. Applying our model to the clinical data of untreated patients, we found that chronic patients have a high cccDNA self-amplification rate. For antiviral treatment, an overall drug effectiveness was introduced and the critical drug effectiveness was obtained. The model predicts that timely long-term therapy is needed to reduce the symptoms of HBV and to maintain the benefits of treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação Viral / Células Dendríticas / DNA Circular / DNA Viral / Vírus da Hepatite B / Modelos Imunológicos / Hepatite B Crônica Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: J Theor Biol Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação Viral / Células Dendríticas / DNA Circular / DNA Viral / Vírus da Hepatite B / Modelos Imunológicos / Hepatite B Crônica Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: J Theor Biol Ano de publicação: 2014 Tipo de documento: Article País de publicação: Reino Unido