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Reduced bone and body mass in young male rats exposed to lead.
de Figueiredo, Fellipe Augusto Tocchini; Gerlach, Raquel Fernanda; da Veiga, Márcia Andreia Mesquita Silva; Nakadi, Flavio Venancio; Ramos, Junia; Kawakita, Erika Reiko; Guerra, Carolina de Souza; Issa, João Paulo Mardegan.
Afiliação
  • de Figueiredo FA; Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • Gerlach RF; Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • da Veiga MA; Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • Nakadi FV; Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • Ramos J; Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • Kawakita ER; Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • Guerra Cde S; Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
  • Issa JP; Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Avenida do Cafe S/N, 14040-904 Ribeirao Preto, SP, Brazil.
Biomed Res Int ; 2014: 571065, 2014.
Article em En | MEDLINE | ID: mdl-24800241
The aim of this study was to see whether there would be differences in whole blood versus tibia lead concentrations over time in growing rats prenatally. Lead was given in the drinking water at 30 mg/L from the time the dams were pregnant until offspring was 28- or 60-day-old. Concentrations of lead were measured in whole blood and in tibia after 28 (28D) and 60 days (60D) in control (C) and in lead-exposed animals (Pb). Lead measurements were made by GF-AAS. There was no significant difference (P > 0.05) in the concentration of whole blood lead between Pb-28D (8.0 ± 1.1 µg/dL) and Pb-60D (7.2 ± 0.89 µg/dL), while both significantly varied (P < 0.01) from controls (0.2 µg/dL). Bone lead concentrations significantly varied between the Pb-28D (8.02 ± 1.12 µg/g) and the Pb-60D (43.3 ± 13.26 µg/g) lead-exposed groups (P < 0.01), while those exposed groups were also significantly higher (P < 0.0001) than the 28D and 60D control groups (Pb < 1 µg/g). The Pb-60D group showed a 25% decrease in tibia mass as compared to the respective control. The five times higher amount of lead found in the bone of older animals (Pb-60D versus Pb-28D), which reinforces the importance of using bone lead as an exposure biomarker.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tíbia / Peso Corporal / Chumbo Limite: Animals / Pregnancy Idioma: En Revista: Biomed Res Int Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tíbia / Peso Corporal / Chumbo Limite: Animals / Pregnancy Idioma: En Revista: Biomed Res Int Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos