A facile and convenient sequential homobimetallic catalytic approach towards ß-methylstyrenes. A one-pot Stille cross-coupling/isomerization strategy.
Org Biomol Chem
; 12(22): 3735-43, 2014 Jun 14.
Article
em En
| MEDLINE
| ID: mdl-24781876
An efficient one-pot synthetic approach towards ß-methylstyrenes is reported. The transformation, based on sequential homobimetallic catalysis, involves a Stille cross-coupling reaction between aryl halides and allyltributylstannane, followed by an in situ palladium-catalyzed conjugative isomerization. The reaction was optimized, and the best results were obtained with 10 mol% Pd(PPh3)2Cl2, 8.0 equiv. LiCl, and 0.5 equiv. PPh3 in diglyme at 130 °C for 12 h. It was demonstrated that the reaction tolerates a wide variety of functional groups.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estirenos
/
Química Orgânica
/
Metais
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Reino Unido