Tobacco experimental model to induce urinary bladder neoplasms.
Rev Col Bras Cir
; 41(1): 56-60, 2014.
Article
em En
| MEDLINE
| ID: mdl-24770775
OBJECTIVE: to develop an experimental model of exposure to tobacco burning (cigarette) products to assess the effects of its chronic use in relation to cancers of the bladder. METHODS: the animals were chronically exposed to the burning tobacco products in a semi-open chamber to simulate smoking. Thirty young Wistar rats were divided into two groups: one with 20 animals simulating smoking for six months, and ten not exposed control animals for the same period. After exposure by inhalation of cigarette smoke, animals were euthanized and subjected to histopathological study of the bladder wall. RESULTS: no tumor was found but mild and non significant alterations. The studies of hemo-oximetry (carboxyhemoglobin and methemoglobin) and the concentration of carbon dioxide (CO2) confirm that the animals were exposed to high concentrations of tobacco smoke and its derivatives. CONCLUSION: no bladder mucosal neoplasia was found in the pathological study of animals. The developed experimental models were highly efficient, practical and easy to use and can be used in other similar studies to determine the harmful effects caused by smoking.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Modelos Animais de Doenças
/
Produtos do Tabaco
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Rev Col Bras Cir
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
Brasil