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CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.
Xia, Mingcan; Hu, Shaomin; Fu, Yaoyao; Jin, Wensen; Yi, Qiyi; Matsui, Yurika; Yang, Jie; McDowell, Mary Ann; Sarkar, Surojit; Kalia, Vandana; Xiong, Na.
Afiliação
  • Xia M; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa.
  • Hu S; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa.
  • Fu Y; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa.
  • Jin W; Teaching and Research Section of Nuclear Medicine, Anhui Medical University, Anhui, China.
  • Yi Q; Teaching and Research Section of Nuclear Medicine, Anhui Medical University, Anhui, China.
  • Matsui Y; Cell and Development Biology Graduate Program, Pennsylvania State University, University Park, Pa.
  • Yang J; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa.
  • McDowell MA; Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Ind.
  • Sarkar S; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa.
  • Kalia V; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa.
  • Xiong N; Centre for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pa. Electronic address: nux1@psu.edu.
J Allergy Clin Immunol ; 134(3): 634-644.e10, 2014 Sep.
Article em En | MEDLINE | ID: mdl-24767879
BACKGROUND: CCR10 and CCL27 make up the most skin-specific chemokine receptor/ligand pair implicated in skin allergy and inflammatory diseases, including atopic dermatitis and psoriasis. This pair is thought to regulate the migration, maintenance, or both of skin T cells and is suggested to be therapeutic targets for treatment of skin diseases. However, the functional importance of CCR10/CCL27 in vivo remains elusive. OBJECTIVE: We sought to determine the expression and function of CCR10 in different subsets of skin T cells under both homeostatic and inflammatory conditions to gain a mechanistic insight into the potential roles of CCR10 during skin inflammation. METHODS: Using heterozygous and homozygous CCR10 knockout/enhanced green fluorescent protein knockin mice, we assessed the expression of CCR10 on regulatory and effector T cells of healthy and inflamed skin induced by chemicals, pathogens, and autoreactive T cells. In addition, we assessed the effect of CCR10 knockout on the maintenance and functions of different T cells and inflammatory status in the skin during different phases of the immune response. RESULTS: CCR10 expression is preferentially induced on memory-like skin-resident T cells and their progenitors for their maintenance in homeostatic skin but not expressed on most skin-infiltrating effector T cells during inflammation. In CCR10 knockout mice the imbalanced presence and dysregulated function of resident regulatory and effector T cells result in over-reactive and prolonged innate and memory responses in the skin, leading to increased clearance of Leishmania species infection in the skin. CONCLUSION: CCR10 is a critical regulator of skin immune homeostasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Subpopulações de Linfócitos T / Linfócitos T Reguladores / Dermatite Atópica / Receptores CCR10 Limite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Subpopulações de Linfócitos T / Linfócitos T Reguladores / Dermatite Atópica / Receptores CCR10 Limite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos