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Colonoscopy and carcinoembryonic antigen variations.
Sousa, Rita G; Nunes, Ana; Meira, Tânia; Carreira, Olga; Pires, Ana M; Freitas, João.
Afiliação
  • Sousa RG; Departamento de Gastroenterologia, Lisboa, Lisboa, Portugal.
  • Nunes A; Departamento de Gastroenterologia, Lisboa, Lisboa, Portugal.
  • Meira T; Departamento de Gastroenterologia, Lisboa, Lisboa, Portugal.
  • Carreira O; Departamento de Patologia Clinica, Hospital Garcia de Orta, Almada, Setúbal, Portugal.
  • Pires AM; Departmento de Matemática e Centro de Matemática e Aplicações - CEMAT, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Lisboa, Portugal.
  • Freitas J; Departamento de Gastroenterologia, Lisboa, Lisboa, Portugal.
Arq Gastroenterol ; 51(1): 69-72, 2014.
Article em En | MEDLINE | ID: mdl-24760068
CONTEXT: Colonoscopy is essential for synchronous and metachronous cancer detection. Carcinoembryonic antigen is a colorectal cancer tumor marker, important as a follow-up tool in patients with previous colorectal cancer. False-positive carcinoembryonic antigen elevation results in multiples exams and in patient anxiety. In literature, there is reference to transient carcinoembryonic antigen increase with colonoscopy. OBJECTIVE: To evaluate the influence of bowel preparation and colonoscopy in carcinoembryonic antigen blood levels. METHODS: We prospectively studied subjects that underwent routine colonoscopy in our institution. Blood samples were collected (1) before bowel cleaning, (2) before colonoscopy and (3) immediately after colonoscopy. Blood carcinoembryonic antigen levels were determined by "Sandwich" immunoassay. The statistical methods used were the paired t-test and ANOVA. RESULTS: Thirty-seven patients (22M/15F) were included; age range 28-84 (mean 56 years). Mean carcinoembryonic antigen values were 1.9, 2 and 1.8 for (1), (2) and (3), respectively. An increase in value (2) compared with (1) was observed in 20/37 patients (P = 0.018), mainly in younger patients and in patients requiring more endoluminal interventions. In 29/37 patients, the CEA value decreased from (2) to (3) (P = 1.3x10-7). CONCLUSIONS: A trend for carcinoembryonic antigen increase after bowel cleaning was observed, especially in younger patients and in patients with more endoluminal interventions, but without clinical meaning.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Antígeno Carcinoembrionário / Colonoscopia Tipo de estudo: Observational_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Portugal País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Antígeno Carcinoembrionário / Colonoscopia Tipo de estudo: Observational_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Portugal País de publicação: Brasil