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Association of the UCP polymorphisms with susceptibility to obesity: case-control study and meta-analysis.
Brondani, Leticia de Almeida; de Almeida Brondani, Letícia; de Souza, Bianca Marmontel; Assmann, Taís Silveira; Bouças, Ana Paula; Bauer, Andrea Carla; Canani, Luís Henrique; Crispim, Daisy.
Afiliação
  • Brondani LA; Endocrinology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Mol Biol Rep ; 41(8): 5053-67, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24752406
This paper describes a case-control study and a meta-analysis performed to evaluate if the following polymorphisms are associated with presence of obesity: -3826A/G (UCP1); -866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3). The case-control study enrolled 282 obese and 483 non-obese patients with type 2 diabetes. A literature search was made to identify all studies that evaluated associations between UCP1-3 polymorphisms and obesity. In the case-control study the distributions of the UCP variants did not differ between obese and non-obese groups (P > 0.05). Forty-seven studies were eligible for the meta-analysis and the results showed that the UCP2 -866G/A and UCP3 -55C/T polymorphisms were associated with protection to obesity in Europeans (OR = 0.89, 95% CI 0.82-0.97 and OR = 0.88, 95% CI 0.80-0.97, respectively). The UCP2 Ala55 val polymorphism was associated with obesity in Asians (OR = 1.61, 95% CI 1.13-2.30). The UCP2 Ins/Del polymorphism was associated with obesity mainly in Europeans (OR = 1.19, 95% CI 1.00-1.42). There was no significant association of the UCP1 -3826A/G polymorphism with obesity. In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Proteínas Mitocondriais / Canais Iônicos / Obesidade Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Biol Rep Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Proteínas Mitocondriais / Canais Iônicos / Obesidade Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Biol Rep Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda