[Treatment of acute full-thickness chondral defects with high molecular weight hyaluronic acid; an experimental model]. / Tratamiento de lesiones condrales agudas de espesor completo con ácido hialurónico de alto peso molecular; un modelo experimental.
Rev Esp Cir Ortop Traumatol
; 58(5): 261-6, 2014.
Article
em Es
| MEDLINE
| ID: mdl-24726031
PURPOSE: To evaluate the effect of 2 different protocols of intra-articular hyaluronic acid (HA, hylan G-F20) to articular cartilage regeneration in acute full-thickness chondral defects. MATERIALS AND METHODS: Full-thickness chondral defects of 3 x 6 mm were performed into the lateral femoral condyles of New Zealand rabbits, treated with a single or three doses of HA. The animals were sacrified at 12 weeks and the regenerated tissue was evaluated by direct observation and histology with the ICRS scale. Macroscopically, in both groups treated with HA the defects were filled with irregular tissue with areas similar to hyaline cartilage and others in which depressed areas with exposed subchondral bone were observed. Histological analysis showed in both groups treated with HA a hyaline-like cartilage compared to control group. However, the score of the International Cartilage Repair Society (ICRS) scale did not show differences between the groups treated with HA. CONCLUSION: The use of single dose or 3 doses of AH in acute chondral lesions has a limited and similar benefit in articular cartilage regeneration.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Cartilagem Articular
/
Viscossuplementos
/
Ácido Hialurônico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Es
Revista:
Rev Esp Cir Ortop Traumatol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Chile
País de publicação:
Espanha